6-HYDROXY-2-BENZOXAZOLINONE 97

Base Information

• Chemical Name: 6-HYDROXY-2-BENZOXAZOLINONE 97
• CAS No.: 78213-03-3
• Molecular Formula: C7H5 N O3
• Molecular Weight: 151.122
• Hs Code.: 2934999090
• Mol file: 78213-03-3.mol

Synonyms:2-Benzoxazolinone,6-hydroxy- (6CI); 6-Hydroxy-2,3-dihydrobenzoxazol-2-one; NSC 603719

Chemical Property of 6-HYDROXY-2-BENZOXAZOLINONE 97

Chemical Property:

• Melting Point: >300 °C(lit.)
• PKA: 8.87±0.70(Predicted)
• PSA: 66.23000
• Density: 1.503g/cm³
• LogP: 0.82670

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Hydroxy-2-benzoxazolinone ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 6-HYDROXY-2-BENZOXAZOLINONE is a useful research chemical.

Technology Process of 6-HYDROXY-2-BENZOXAZOLINONE 97

There total 3 articles about 6-HYDROXY-2-BENZOXAZOLINONE 97 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

benzoxazole (273-53-0,29791-96-6) → 2-Benzoxazolinone (59-49-4) + 6-hydroxybenzo[d]oxazol-2(3H)-one (78213-03-3) + 3-(2'-oxo-2',3'-dihydrobenzoxazol-6'-yl)benzoxazol-2(3H)-one (106050-82-2) + 6-hydroxybenzoxazole (106050-81-1)

Guidance literature:

With lead(IV) acetate; acetic acid; at 80 ℃; for 8h; Further byproducts given;

Reference yield: 6.0%

benzoimidazole (51-17-2,79351-71-6) → 2-Benzoxazolinone (59-49-4) + 6-hydroxybenzo[d]oxazol-2(3H)-one (78213-03-3) + 3-(2'-oxo-2',3'-dihydrobenzoxazol-6'-yl)benzoxazol-2(3H)-one (106050-82-2) + 6-hydroxybenzoxazole (106050-81-1)

Guidance literature:

With lead(IV) acetate; acetic acid; at 80 ℃; for 8h; Further byproducts given;

Reference yield:

2-[4-(6-Chloro-benzooxazol-2-yloxy)-phenoxy]-propionic acid ethyl ester (66441-23-4,113776-20-8,116573-18-3,82110-72-3) → 4-(6-chlorobenzo[d]oxazol-2-yloxy)phenol (70217-01-5) + ethyl 2-{4-[(2-benzoxazolyl)oxy]phenoxy}propanoate (66441-21-2) + 2-Benzoxazolinone (59-49-4) + 6-chlorobenzo[d]oxazol-2(3H)-one (19932-84-4) + 6-hydroxybenzo[d]oxazol-2(3H)-one (78213-03-3) + 4-[(6-hydroxy-2-benzoxazolyl)oxy]phenol (1051401-34-3) + ethyl 2-{4-[(6-hydroxy-2-benzoxazolyl)oxy]phenoxy}propanoate (1051401-33-2) + hydroquinone (123-31-9,8027-02-9) + ethyl 2-(4-hydroxyphenoxy)propanoate (65343-67-1)

Guidance literature:

In water; acetonitrile; Irradiation;

DOI:10.1021/jf801341s

upstream raw materials:

benzoxazole

benzoimidazole

2-[4-(6-Chloro-benzooxazol-2-yloxy)-phenoxy]-propionic acid ethyl ester

Downstream raw materials:

6-(benzyloxy)benzo[d]oxazol-2(3H)-one

Refernces

• 1、 Cole, Edward R.,Crank, George,Sumantri. "Oxidations with Lead Tetraacetate. VI. Oxidations of Benzimidazoles, Benzoxazoles and Benzothiazoles". . p. 295 - 301. Retrieved 2007/10/02.