3-Aminopyrrolidine dihydrochloride

Base Information

• Chemical Name: 3-Aminopyrrolidine dihydrochloride
• CAS No.: 103831-11-4
• Molecular Formula: C₄H₁₀N₂*2ClH
• Molecular Weight: 159.059
• Hs Code.: 29339900
• Mol file: 103831-11-4.mol

Synonyms:3-Pyrrolidinamine,dihydrochloride (9CI);3-Pyrrolidinamine,hydrochloride (1:2);

Chemical Property of 3-Aminopyrrolidine dihydrochloride

Chemical Property:

• Appearance/Colour: off-white to cream colored crystalline powder
• Vapor Pressure: 1.24mmHg at 25°C
• Melting Point: >300 °C
• Refractive Index: 1.6300 (estimate)
• Boiling Point: 214.5 °C at 760 mmHg
• Flash Point: 83.5 °C
• PSA: 38.05000
• Density: 1.413
• LogP: 1.94010
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Hygroscopic
• Water Solubility.: almost transparency

Purity/Quality:

99% ^*data from raw suppliers

Pyrrolidin-3-amineDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 3-Aminopyrrolidine dihydrochloride is the suitable reagent used as an internal standard for the quantitative analysis of amino acids in bio-fluids. (R,S) 3-Aminopyrrolidine dihydrochloride may be used in the preparation of cis-[PdCl2(pyrr)] and cis-[PtCl2(pyrr)] (pyrr= (R,S)-3-aminopyrrolidine) complexes.

Technology Process of 3-Aminopyrrolidine dihydrochloride

There total 5 articles about 3-Aminopyrrolidine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.9%

(R)-pyrrolidin-3-amine (116183-82-5) → (3R)-3-aminopyrrolidine dihydrochloride (103831-11-4,116183-81-4,116183-83-6,122458-34-8)

Guidance literature:

With hydrogenchloride; In ethanol; at 10 - 40 ℃;

Reference yield: 80.5%

(3R)-3-azido-1-(phenylmethyl)pyrrolidine (116143-03-4) → (3R)-3-aminopyrrolidine dihydrochloride (103831-11-4,116183-81-4,116183-83-6,122458-34-8)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; for 2.5h; under 760 Torr;

DOI:10.1021/jm00100a028

Reference yield:

(3S)-3-azido-1-(phenylmethyl)pyrrolidine (114636-29-2) → (S)-3-aminopyrrolidine dihydrochloride (103831-11-4,116183-81-4,116183-83-6,122458-34-8)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; for 2.5h; under 760 Torr;

DOI:10.1021/jm00100a028

upstream raw materials:

(3S)-3-azido-1-(phenylmethyl)pyrrolidine

(3R)-3-azido-1-(phenylmethyl)pyrrolidine

(R)-pyrrolidin-3-amine

Downstream raw materials:

(3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine

1-(3-amino-4,6-difluorophenyl)-7-[(3S)-3-aminopyrrolidin-1-yl]-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid triethylamine salt

2-{[(3R)-3-aminopyrrolidin-1-yl]carbonyl}-3-[(2,4-difluorophenyl)amino]-7-phenylthieno[2,3-b]pyridin-6(7H)-one

N-((3R)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-3-pyrrolidinyl)-3,4-bis(methyloxy)benzenesulfonamide

Refernces

• 1、 Cesare, P. Di,Bouzard, D.,Essiz, M.,Jacquet, J. P.,Ledoussal, B.,et al.. "Fluoronaphthyridines and -quinolines as Antibacterial Agents. 5. Synthesis and Antimicrobial Activity of Chiral 1-tert-Butyl-6-fluoro-7-substituted-naphthyridones". . p. 4205 - 4213. Retrieved 2007/10/02.