Technology Process of Milbemycin D
There total 17 articles about Milbemycin D which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate;
In
methanol;
at 0 ℃;
for 0.166667h;
DOI:10.1021/ja961071u
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 79 percent / Pr4NRuO4, NMO, 4 Angstroem molecular sieves / CH2Cl2 / 4 h / Ambient temperature
2: Et3N / CH2Cl2 / 8 h / 0 °C
3: 0.023 g / CH2Cl2 / 1 h / -78 °C
4: 66 percent / aq. 48percent HF, pyridine / acetonitrile / 24 h / Ambient temperature
5: NaIO4 / tetrahydrofuran; H2O / 2 h / Ambient temperature
6: 32 percent / NaBH4 / methanol / 0.17 h / 0 °C
With
pyridine; sodium tetrahydroborate; sodium periodate; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve; hydrogen fluoride; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/ja961071u
- Guidance literature:
-
Multi-step reaction with 5 steps
1: Et3N / CH2Cl2 / 8 h / 0 °C
2: 0.023 g / CH2Cl2 / 1 h / -78 °C
3: 66 percent / aq. 48percent HF, pyridine / acetonitrile / 24 h / Ambient temperature
4: NaIO4 / tetrahydrofuran; H2O / 2 h / Ambient temperature
5: 32 percent / NaBH4 / methanol / 0.17 h / 0 °C
With
pyridine; sodium tetrahydroborate; sodium periodate; hydrogen fluoride; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/ja961071u
