6-fluorohexanenitrile

Base Information

• Chemical Name: 6-fluorohexanenitrile
• CAS No.: 373-31-9
• Molecular Formula: C6H10FN
• Molecular Weight: 115.1487
• Mol file: 373-31-9.mol

Synonyms:

Chemical Property of 6-fluorohexanenitrile

Chemical Property:

• Vapor Pressure: 0.681mmHg at 25°C
• Boiling Point: 185.9°Cat760mmHg
• Flash Point: 67.2°C
• Density: 0.91g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-fluorohexanenitrile

There total 4 articles about 6-fluorohexanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-Chloro-5-fluoropentane (407-98-7) + sodium cyanide (143-33-9,25596-52-5) → 6-Fluorohexanenitrile (373-31-9)

Guidance literature:

With sodium iodide; In ethanol; for 18h; Heating;

DOI:10.1016/S0022-1139(96)03457-4

Reference yield: 78.0%

(5-cyanopentyl)boronic acid → 6-Fluorohexanenitrile (373-31-9)

Guidance literature:

With phosphoric acid; silver nitrate; Selectfluor; In dichloromethane; water; at 50 ℃; for 8h; Schlenk technique; Inert atmosphere;

DOI:10.1021/ja509548z

Reference yield:

1,5-dichloropentane (628-76-2) → 6-Fluorohexanenitrile (373-31-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 18 percent / KF / bis-(2-hydroxy-ethyl) ether / 125 °C / 3.9 Torr

2: 85 percent / NaI / aq. ethanol / 18 h / Heating

With potassium fluoride; sodium iodide; In ethanol; diethylene glycol;

DOI:10.1016/S0022-1139(96)03457-4

upstream raw materials:

1-bromo-5-fluoropentane

sodium cyanide

1-Chloro-5-fluoropentane

1,5-dichloropentane

Downstream raw materials:

1-Amino-6-fluorohexane

methyl 6-fluorohexanoate

6-fluoro hexanoic acid

Refernces

• 1、 Windhorst,Bechger,Visser,Menge,Leurs,Timmerman,Herscheid. "Approaches towards the synthesis of fluoro(cyclo)alkylamines". . p. 35 - 40. Retrieved 2007/10/03.