1,2,3,4-Tetrahydroisoquinoline-1,3-dione

Base Information

• Chemical Name: 1,2,3,4-Tetrahydroisoquinoline-1,3-dione
• CAS No.: 4456-77-3
• Molecular Formula: C9H7NO2
• Molecular Weight: 161.16
• Hs Code.: 2933499090
• Mol file: 4456-77-3.mol

Synonyms:Homophthalimide;1,2,3,4-Tetrahydro-1,3-dioxoisoquinoline;Isoquinoline-1,3(2H,4H)-dione;1,3[2H,4H]-Isoquinolinedione;4H-Isoquinoline-1,3-dione;1,3(2H,4H)-Isoquinolinedione;

Chemical Property of 1,2,3,4-Tetrahydroisoquinoline-1,3-dione

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 223 °C
• Refractive Index: 1.586
• Boiling Point: 377.148 °C at 760 mmHg
• PKA: 10.25±0.20(Predicted)
• Flash Point: 183.887 °C
• PSA: 46.17000
• Density: 1.286 g/cm³
• LogP: 0.82790
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

Isoquinoline-1,3(2H,4H)-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2,3,4-Tetrahydroisoquinoline-1,3-dione

There total 29 articles about 1,2,3,4-Tetrahydroisoquinoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

homophthalic anhydride (703-59-3) → 4H-isoquinolin-1,3-dione (4456-77-3)

Guidance literature:

With ammonium carbonate;

Reference yield: 90.0%

Homophthalic acid (89-51-0) → 4H-isoquinolin-1,3-dione (4456-77-3)

Guidance literature:

With ammonium hydroxide; In 1,2-dichloro-benzene; at 175 ℃; Microwave irradiation;

DOI:10.1007/s00044-020-02662-w

Reference yield: 87.0%

indan-1,2-dione-2-oxime (15028-10-1) → 4H-isoquinolin-1,3-dione (4456-77-3)

Guidance literature:

With silica gel; molybdenum(VI) oxide; In ethanol; Heating;

DOI:10.1016/j.tetlet.2004.04.068

upstream raw materials:

2-carbamoylmethyl-benzoic acid methyl ester

2-carbamoylmethyl-benzoic acid

methyl 3-methyl-1-oxo-1H-isochromene-4-carboxylate

Homophthalic acid

Downstream raw materials:

4-phenylmethylene-1,2,3,4-tetrahydroisoquinoline-1,3-dione

4,4-dibenzyl-4H-isoquinoline-1,3-dione

Diallylhomophthalid

isoquinoline

Refernces

• 1、 -. "FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF". . . Retrieved 2021/02/12.
• 2、 Kennedy, Sean H.,Schaeff, Mark N.,Klumpp, Douglas A.. "Superelectrophiles in Synthesis: Preparation of Aromatic Imides". . p. 14133 - 14140. Retrieved 2019/10/16.