2-AMINO-5,6-DIMETHYL-4-HYDROXYPYRIMIDINE

Base Information

• Chemical Name: 2-AMINO-5,6-DIMETHYL-4-HYDROXYPYRIMIDINE
• CAS No.: 3977-23-9
• Molecular Formula: C6H9N3O
• Molecular Weight: 139.157
• Hs Code.: 2933599090
• Mol file: 3977-23-9.mol

Synonyms:4(1H)-Pyrimidinone, 2-amino-5,6-dimethyl-;4 (1H)-Pyrimidinone, 2-amino-5,6-dimethyl-;4-Pyrimidinol, 2-amino-5,6-dimethyl- (8CI);2-Amino-5,6-dimethyl-1H-pyrimidin-4-one;2-Amino-5,6-dimethylpyrimidin-4(1H)-one;

Chemical Property of 2-AMINO-5,6-DIMETHYL-4-HYDROXYPYRIMIDINE

Chemical Property:

• Vapor Pressure: 0.0134mmHg at 25°C
• Melting Point: 333-337 °C(lit.)
• Refractive Index: 1.625
• Boiling Point: 258.9 °C at 760 mmHg
• PKA: 10.18±0.50(Predicted)
• Flash Point: 110.4 °C
• PSA: 72.03000
• Density: 1.36 g/cm³
• LogP: 0.96240

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-amino-5,6-dimethylpyrimidin-4(3H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2-AMINO-5,6-DIMETHYL-4-HYDROXYPYRIMIDINE

There total 6 articles about 2-AMINO-5,6-DIMETHYL-4-HYDROXYPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-acetoacetic acid methyl ester (17094-21-2) + guanidine hydrochloride (50-01-1) → 2‐amino‐5,6‐dimethyl‐4‐hydroxypyrimidine (3977-23-9)

Guidance literature:

With potassium tert-butylate; In methanol; at 23 - 60 ℃;

DOI:10.1021/jm401727m

Reference yield:

→ 2‐amino‐5,6‐dimethyl‐4‐hydroxypyrimidine (3977-23-9)

Guidance literature:

Guanidinsulfat, 2-Methylacetessigsaeureethylester;

Reference yield:

2-acetylpropanoic acid ethyl ester (609-14-3) + guanidinium sulfate (594-14-9,1184-68-5) → 2-amino-5,6-dimethyl-4(3H)-pyrimidinone (3977-23-9)

Guidance literature:

With sodium ethanolate; In ethanol;

DOI:10.1016/S0040-4020(00)00288-X

upstream raw materials:

2-acetylpropanoic acid ethyl ester

diguanidine carbonate

guanidinium sulfate

2-methyl-acetoacetic acid methyl ester

Downstream raw materials:

2-amino-4-chloro-5,6-dimethyl-pyrimidine

N-acetyl-sulfanilic acid-(4-methoxy-5,6-dimethyl-pyrimidin-2-ylamide)

Refernces

• 1、 Savall, Brad M.,Chavez, Frank,Tays, Kevin,Dunford, Paul J.,Cowden, Jeffery M.,Hack, Michael D.,Wolin, Ronald L.,Thurmond, Robin L.,Edwards, James P.. "Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H 4 receptor antagonists". . p. 2429 - 2439. Retrieved 2014/04/17.