Minimycin

Base Information

• Chemical Name: Minimycin
• CAS No.: 32388-21-9
• Molecular Formula: C₉H₁₁NO₇
• Molecular Weight: 245.189
• DSSTox Substance ID: DTXSID10186102
• Nikkaji Number: J54.251B
• Wikidata: Q83057302
• Metabolomics Workbench ID: 98083
• ChEMBL ID: CHEMBL3144030
• Mol file: 32388-21-9.mol

Synonyms:5 beta-d-ribofuranosyl-1,3-oxazin-2,4-dione;minimycin;oxazinomycin

Chemical Property of Minimycin

Chemical Property:

• Melting Point: 165°C (rough estimate)
• Refractive Index: 1.5270 (estimate)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 133.25000
• Density: 1.705g/cm³
• LogP: -2.10560
• XLogP3: -2.2
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 2
• Exact Mass: 245.05355169
• Heavy Atom Count: 17
• Complexity: 380

Purity/Quality:

99% ^*data from raw suppliers

MINIMYCIN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=O)NC(=O)O1)C2C(C(C(O2)CO)O)O
• Isomeric SMILES: C1=C(C(=O)NC(=O)O1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O
• Uses: Minimycin is an antibiotic isolated from the culture broth of Streptomyces hygroscopicus. It is active against both gram-positive and gram-negative bacteria, and also possesses significant antitumor activity against transplantable tumors.

Technology Process of Minimycin

There total 2 articles about Minimycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(O2,O3-isopropylidene-O5-trityl-β-D-ribofuranosyl)-[1,3]oxazine-2,4-dione (60526-12-7) → oxazinomycin (32388-21-9)

Guidance literature:

With trifluoroacetic acid;

DOI:10.1021/jo00421a021

Reference yield:

→ oxazinomycin (32388-21-9)

Guidance literature:

Mikrobiol. Herst. durch Streptomyces;

upstream raw materials:

5-(O²,O³-isopropylidene-O⁵-trityl-β-D-ribofuranosyl)-[1,3]oxazine-2,4-dione

Refernces