Technology Process of 2-Cyclohexene-1-carboxylic acid,
1-(3-chloropropyl)-2-(trimethylstannyl)-, methyl ester
There total 1 articles about 2-Cyclohexene-1-carboxylic acid,
1-(3-chloropropyl)-2-(trimethylstannyl)-, methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ammonium chloride;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
Ar; addn. of a solution of the ester to a cold (-48 ° C) stirred solution of LDA in HMPA/THF; stirring at -48 ° C for 40 min; addn. of 1-chloro-3-iodopropane; stirring at this temperature for 40 min;; addn. of saturated aqueous NH4Cl; dilution at room temperature with Et2O; washing of the mixture with CuSO4, water, brine; drying (MgSO4), concentration; flash chromy., followed by distillation (125-135 ° C/0.1 Torr);
- Guidance literature:
-
With
ammonium chloride;
In
diethyl ether; hexane;
Ar; addn. of a solution of i-Bu2AlH in hexanes to a solution of the starting compound in ether at -20 ° C; stirring at -20 ° C for 1 h;; addn. of aqueous NH4Cl, stirring at rrom temperature until the organic phase was clear; filtration (florisil, ether); concentration; distillation (125-130 ° C/0.1 Torr);;
