Octamethyltrisiloxane

Base Information

• Chemical Name: Octamethyltrisiloxane
• CAS No.: 107-51-7
• Deprecated CAS: 1463470-58-7
• Molecular Formula: C8H24O2Si3
• Molecular Weight: 236.534
• Hs Code.: 29319090
• European Community (EC) Number: 203-497-4,613-156-5,687-578-3
• UNII: 9G1ZW13R0G
• DSSTox Substance ID: DTXSID9040710
• Nikkaji Number: J99.786B
• Wikidata: Q2013799
• NCI Thesaurus Code: C83674
• RXCUI: 1368190,1363569
• Metabolomics Workbench ID: 67691
• ChEMBL ID: CHEMBL2142985
• Mol file: 107-51-7.mol

Synonyms:baysilon;Macroplastique;poly(dimethylsiloxane);polydimethylsiloxane;RTV S-5392;Silastic;siliconique;Silikon 1000;Simpa

Chemical Property of Octamethyltrisiloxane

Chemical Property:

• Appearance/Colour: clear colourless liquid
• Vapor Pressure: 4.36mmHg at 25°C
• Melting Point: -82 °C
• Refractive Index: n20/D 1.384(lit.)
• Boiling Point: 152.999 °C at 760 mmHg
• Flash Point: 55.016 °C
• PSA: 18.46000
• Density: 0.843 g/cm³
• LogP: 3.39120
• Storage Temp.: Flammables area
• Solubility.: Chloroform (Slightly), DMSO, Methanol (Slightly)
• Water Solubility.: 34μg/L at 23℃
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 236.10840961
• Heavy Atom Count: 13
• Complexity: 149

Purity/Quality:

99.9% ^*data from raw suppliers

Octamethyltrisiloxane ^*data from reagent suppliers

Safty Information:

• Statements: 10
• Safety Statements: 23-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Metals -> Metalloid Compounds (Silicon)
• Canonical SMILES: C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C
• Recent EU Clinical Trials: A randomised, active-controlled, observer-blind, non-inferiority study to investigate the efficacy, safety and tolerability of a local treatment with dimeticone-based pediculicides in head lice infestation.
• Recent NIPH Clinical Trials: A clinical trial with two treatments of tungiasis in Homa Bay, Kenya
• Uses: Octamethyltrisiloxane is a linear silicone oligomer. It is used as an excipient Dimethicones in pharmaceutical and cosmetic applications can provide long lasting lubricant, smooth feel and spreads easily. Studies demonstrate that it is able to maintain the conformational stability of certain adsorbed proteins such as bovine serum albumin (BSA). Used in the methylation of mercury(II) salts.

Technology Process of Octamethyltrisiloxane

There total 48 articles about Octamethyltrisiloxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.8%

1,1,1,2,2,2-hexamethyldisilane (1450-14-2) → tetramethylsilane (75-76-3) + Hexamethyldisiloxane (107-46-0) + octamethyltrisiloxabe (107-51-7) + Hexamethylcyclotrisiloxane (541-05-9) + decamethyltetrasiloxane (141-62-8)

Guidance literature:

With carbon monoxide; nickel; at 200 ℃; for 2h; under 750.06 Torr; Product distribution; various reagents and reaction conditions;

Reference yield:

chloro-trimethyl-silane (75-77-4) + sodiumoxydimethylethoxysilane (121954-25-4) → ethyl trimethylsilyl ether (1825-62-3) + diethoxy dimethylsilane (78-62-6) + Hexamethyldisiloxane (107-46-0) + octamethyltrisiloxabe (107-51-7)

Guidance literature:

sodiumoxydimethylethoxysilane; at 70 - 200 ℃; Thermolysis;

chloro-trimethyl-silane; In pentane; at -30 ℃; Further byproducts given;

DOI:10.1002/hc.20280

Reference yield:

Hexamethyldisiloxane (107-46-0) + octamethylcyclotetrasiloxane (556-67-2) → octamethyltrisiloxabe (107-51-7) + decamethyltetrasiloxane (141-62-8) + dodecamethylpentasiloxane (141-63-9) + tetradecamethylhexasiloxane (107-52-8) + hexadecamethylheptasiloxane (541-01-5)

Guidance literature:

With sulfuric acid; antimony(V) chloride; In tetrachloromethane; sulfuric acid; shaking of (CH3)3SiOSi(CH3)3 and ((CH3)2SiO)4 (1:1 mol) with concd. H2SO4 at 25°C for 8 days; equilibrium react.; further products;;

DOI:10.1021/ja01215a050

upstream raw materials:

dimethyldibromosilane

Hexamethyldisiloxane

octamethylcyclotetrasiloxane

Perbenzoic acid

Downstream raw materials:

octamethylcyclotetrasiloxane

chloro-trimethyl-silane

phenyl(pentamethyldisiloxanyl)fluorochlorosilane

trimethylsilyl iodide

Refernces

• 1、 Krasnova,Chernyshev,Sergeev. "1,1,1-Trimethyl-3,3,3-trichlorodisiloxane as a source and a trapping agent for silanones". . p. 1238 - 1239. Retrieved 1996.
• 2、 Voronkov,Romanova,Dubinskaya. "Reaction of dimethyldichlorosilane with hexamethyldisiloxane as a source of dimethylsilanone. A route to linear and cyclic polydimethylsiloxanes [4]". . p. 1156 - 1157. Retrieved 2003.
• 3、 Scott, D. W.. "". . p. 2294 - 2298. Retrieved 1946.
• 4、 -. "Method for producing polyimidesiloxane". Paragraph 0040. . Retrieved 2018/10/16.