Alagebrium chloride

Base Information

• Chemical Name: Alagebrium chloride
• CAS No.: 341028-37-3
• Molecular Formula: C13H14NOS.Cl
• Molecular Weight: 267.77
• Hs Code.: 2934100090
• European Community (EC) Number: 636-473-0
• UNII: 79QS8K2877
• DSSTox Substance ID: DTXSID60955648
• Wikipedia: Alagebrium
• Wikidata: Q25717
• NCI Thesaurus Code: C75185
• ChEMBL ID: CHEMBL2107309
• Mol file: 341028-37-3.mol

Synonyms:3-phenacyl-4,5-dimethylthiazolium chloride;alagebrium;ALT 711;ALT-711;ALT711;phenyl-4,5-dimethylthiazolium chloride

Chemical Property of Alagebrium chloride

Chemical Property:

• Melting Point: 212 °C(dec.)
• PSA: 49.19000
• LogP: -0.46070
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 267.0484629
• Heavy Atom Count: 17
• Complexity: 250

Purity/Quality:

99% ^*data from raw suppliers

Alagebrium Chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(SC=[N+]1CC(=O)C2=CC=CC=C2)C.[Cl-]
• Recent ClinicalTrials: Effects of Exercise Training and AGE-crosslink Breaker on Cardiovascular Structure and Function
• Recent EU Clinical Trials: A Randomozed, Placebo-Controlled Trial of Alagebrium in Patients with Insulin-Dependent Type 1 Diabetes and Microalbuminuria
• Uses: Prevention and treatment of cardiovascular complications of aging, diabetes, and end stage renal disease; diabetic multisymptom pathology (other than cardiovascular) including retinopathy, neuphropathy, neuropathy, and ulcers (advanced glycosylation endpr. Alagebrium Chloride is used in the treatment of obesity resulting from a diet high in both fat and AGE that causes renal impairment in animals. Alagebrium inhibits AGE-mediated formation of reactive oxygen species (ROS), extracellular signal-regulated kinase phosphorylation, and cyclooxygenase-2 expression.