2-(biphenyl-4-yl)-2-oxoethyl 4-hydroxybenzoate

Base Information

• Chemical Name: 2-(biphenyl-4-yl)-2-oxoethyl 4-hydroxybenzoate
• CAS No.: 4347-81-3
• Molecular Formula: C21H16 O4
• Molecular Weight: 332.3493
• Mol file: 4347-81-3.mol

Synonyms:Benzoicacid, p-hydroxy-, ester with2-hydroxy-4'-phenylacetophenone (7CI,8CI); NSC 406819

Chemical Property of 2-(biphenyl-4-yl)-2-oxoethyl 4-hydroxybenzoate

Chemical Property:

• Vapor Pressure: 1.35E-13mmHg at 25°C
• Boiling Point: 570°C at 760 mmHg
• Flash Point: 206.5°C
• Density: 1.244g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(biphenyl-4-yl)-2-oxoethyl 4-hydroxybenzoate

There total 3 articles about 2-(biphenyl-4-yl)-2-oxoethyl 4-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.8%

2-Bromo-4'-phenylacetophenone (135-73-9) + 4-hydroxy-benzoic acid (99-96-7) → p-phenylphenacyl 4-hydroxybenzoate (4347-81-3)

Guidance literature:

With potassium fluoride; In N,N-dimethyl-formamide; for 0.5h; Ambient temperature;

DOI:10.1021/ac50064a047

Reference yield:

biphenyl-4-acetaldehyde (92-91-1) → p-phenylphenacyl 4-hydroxybenzoate (4347-81-3)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; bromine / 45 - 50 °C

With bromine; acetic acid;

DOI:10.1021/ja01344a056

Reference yield:

biphenyl (92-52-4,1594-86-1) → p-phenylphenacyl 4-hydroxybenzoate (4347-81-3)

Guidance literature:

Multi-step reaction with 3 steps

1: AlCl₃; carbon disulfide

2: acetic acid; bromine / 45 - 50 °C

With carbon disulfide; aluminium trichloride; bromine; acetic acid;

DOI:10.1021/ja01344a056

upstream raw materials:

2-Bromo-4'-phenylacetophenone

4-hydroxy-benzoic acid

biphenyl-4-acetaldehyde

biphenyl

Refernces