Eflornithine hydrochloride

Base Information

• Chemical Name: Eflornithine hydrochloride
• CAS No.: 68278-23-9
• Deprecated CAS: 70050-56-5
• Molecular Formula: C6H13ClF2N2O2
• Molecular Weight: 218.63
• Hs Code.: 2922499990
• European Community (EC) Number: 269-532-0
• NSC Number: 270295
• UNII: UO07O10TCJ
• DSSTox Substance ID: DTXSID601019072
• Wikidata: Q27291165
• NCI Thesaurus Code: C1579
• RXCUI: 81945
• ChEMBL ID: CHEMBL536971
• Mol file: 68278-23-9.mol

Synonyms:alpha Difluoromethyl Ornithine;alpha Difluoromethylornithine;alpha-Difluoromethyl Ornithine;alpha-Difluoromethylornithine;Difluoromethylornithine;DL alpha Difluoromethylornithine;DL-alpha-Difluoromethylornithine;Eflornithine;Eflornithine Hydrochloride;Eflornithine Monohydrochloride, Monohydrate;MDL 71,782 A;MDL-71,782 A;MDL71,782 A;Ornidyl;Ornithine, alpha-Difluoromethyl;RMI 71782;Vaniqa

Chemical Property of Eflornithine hydrochloride

Chemical Property:

• Appearance/Colour: white solid
• Vapor Pressure: 9.72E-06mmHg at 25°C
• Melting Point: 181-184 °C
• Boiling Point: 347 °C at 760 mmHg
• Flash Point: 163.7 °C
• PSA: 89.34000
• LogP: 1.97510
• Solubility.: H2O: >10 mg/mL, soluble
• Water Solubility.: H2O: >10 mg/mL, soluble
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 218.0633617
• Heavy Atom Count: 13
• Complexity: 166

Purity/Quality:

99% ^*data from raw suppliers

DL-α-DifluoromethylornithineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CC(C(F)F)(C(=O)O)N)CN.Cl
• Recent ClinicalTrials: Irinotecan Hydrochloride, Temozolomide, and Dinutuximab With or Without Eflornithine in Treating Patients With Relapsed or Refractory Neuroblastoma
• Recent EU Clinical Trials: A Phase 3, Randomized, Open-Label Study To Evaluate the Efficacy and Safety of Eflornithine with Lomustine Compared to Lomustine Alone in Patients with Anaplastic Astrocytoma That Progress/Recur After Irradiation and Adjuvant Temozolomide Chemotherapy
• Uses: Antineoplastic; antiprotozoal. DL-alpha-Difluoromethylornithine Hydrochloride is an irreversible inhibitor of ornithine decarboxylase.
• Indications: Vaniqa (eflornithine hydrochloride 13.9%) cream is a unique topical cream that slows anagen hair growth by irreversibly blocking the enzyme ornithine decarboxylase. This enzyme produces polyamines in the hair matrix that are partially responsible for the growth of the anagen hair. The cream was tested only on the upper lip and chin region. The onset of action is usually within 8 weeks of starting the b.i.d. treatment, and the hair growth will return to baseline within 8 weeks of discontinuing the drug. Patients need to be reminded that this product does not remove hair but slows its growth in between whatever they use for hair removal.