Quinoline, 2,6-diphenyl-

Base Information

• Chemical Name: Quinoline, 2,6-diphenyl-
• CAS No.: 94878-29-2
• Molecular Formula: C21H15N
• Molecular Weight: 281.35100
• Mol file: 94878-29-2.mol

Synonyms:2,6-Diphenyl-chinolin;Quinoline,2,6-diphenyl;2,6-diphenyl-quinoline;

Chemical Property of Quinoline, 2,6-diphenyl-

Chemical Property:

• Melting Point: 206-208 °C
• Boiling Point: 465.5±14.0 °C(Predicted)
• PSA: 12.89000
• Density: 1.137±0.06 g/cm3(Predicted)
• LogP: 5.56880

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Quinoline, 2,6-diphenyl-

There total 8 articles about Quinoline, 2,6-diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

acetophenone (98-86-2) + (2-amino-5-bromophenyl)methanol (20712-12-3) + phenylboronic acid (98-80-6) → 2,6-diphenylquinoline (94878-29-2)

Guidance literature:

With C₄₁H₄₇ClFeN₄Pd; copper diacetate; caesium carbonate; In 1,4-dioxane; at 110 ℃; for 20h;

DOI:10.1039/c4ob00231h

Reference yield: 78.0%

6-bromo-2-phenyl-quinoline (3894-25-5) + phenylboronic acid (98-80-6) → 2,6-diphenylquinoline (94878-29-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 90 ℃; Inert atmosphere; Alkaline conditions;

DOI:10.1002/chem.201504392

Reference yield: 75.0%

3-Phenylpropenol (104-54-1) + 4-phenylalanine (92-67-1) → 2,6-diphenylquinoline (94878-29-2)

Guidance literature:

With oxygen; palladium diacetate; In dimethyl sulfoxide; at 130 ℃; for 12h; under 760.051 Torr;

DOI:10.1039/c7ra06425j

upstream raw materials:

acetophenone

(2-amino-5-bromophenyl)methanol

phenylboronic acid

6-bromo-2-phenyl-quinoline

Refernces

• 1、 Xu, Jingxiu,Sun, Jing,Zhao, Jinwu,Huang, Bin,Li, Xiaohan,Sun, Yulun. "Palladium-catalyzed synthesis of quinolines from allyl alcohols and anilines". . p. 36242 - 36245. Retrieved 2017/08/02.
• 2、 Li, Chunsheng,Li, Jianxiao,An, Yanni,Peng, Jianwen,Wu, Wanqing,Jiang, Huanfeng. "Palladium-Catalyzed Allylic C-H Oxidative Annulation for Assembly of Functionalized 2-Substituted Quinoline Derivatives". . p. 12189 - 12196. Retrieved 2016/12/23.