Pheniprazine

Base Information

• Chemical Name: Pheniprazine
• CAS No.: 55-52-7
• Molecular Formula: C9H14 N2
• Molecular Weight: 150.224
• Hs Code.: 2928000090
• European Community (EC) Number: 200-236-6
• UNII: 37VKD7067M
• DSSTox Substance ID: DTXSID6043838
• Nikkaji Number: J4.560H
• Wikipedia: Pheniprazine
• Wikidata: Q7181347
• NCI Thesaurus Code: C80967
• Pharos Ligand ID: MJBGFDVHXH63
• Metabolomics Workbench ID: 152282
• ChEMBL ID: CHEMBL22498
• Mol file: 55-52-7.mol

Synonyms:beta-phenylisopropylhydrazine;JB 516;JB-516;pheniprazine

Chemical Property of Pheniprazine

Chemical Property:

• Vapor Pressure: 0.00253mmHg at 25°C
• Melting Point: 25°C
• Refractive Index: 1.6210 (estimate)
• Boiling Point: 287.1°Cat760mmHg
• Flash Point: 148°C
• PSA: 38.05000
• Density: 0.99g/cm³
• LogP: 2.17210
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 150.115698455
• Heavy Atom Count: 11
• Complexity: 97.7

Purity/Quality:

98%min ^*data from raw suppliers

1-(1-phenylpropan-2-yl)hydrazine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC=CC=C1)NN
• Therapeutic Function: Antihypertensive

Technology Process of Pheniprazine

There total 14 articles about Pheniprazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1-phenylpropan-2-ylidene)hydrazine (5171-99-3) → pheniprazine (55-52-7)

Guidance literature:

With ethanol; platinum; Hydrogenation;

DOI:10.1021/ja01520a048

Reference yield:

1-phenyl-acetone (103-79-7,136675-26-8) → pheniprazine (55-52-7)

Guidance literature:

Multistep reaction; (i) N₂H₄*H₂O, EtOH, (ii) H₂, PtO₂, Pd-C;

Reference yield:

N-Benzhydrylidene-N'-(1-methyl-2-phenyl-ethyl)-hydrazine → pheniprazine (55-52-7)

Guidance literature:

With hydrogenchloride; In ethanol; at 25 ℃; for 15h; Yield given;

DOI:10.1039/c39860000176

upstream raw materials:

(1-phenylpropan-2-ylidene)hydrazine

3-(1-methyl-2-phenyl-ethyl)-sydnone

1-phenylpropene

1-phenyl-acetone

Downstream raw materials:

3-methyl-isoxazole-5-carboxylic acid N'-(1-methyl-2-phenyl-ethyl)-hydrazide

2-Methansulfonyl-1-(1-methyl-2-phenylethyl)hydrazin

N-(3-chlorophenyl)-1-(2-phenylpropyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

1-(2-phenylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

Refernces

• 1、 Radi, Marco,Dreassi, Elena,Brullo, Chiara,Crespan, Emmanuele,Tintori, Cristina,Bernardo, Vincenzo,Valoti, Massimo,Zamperini, Claudio,Daigl, Henry,Musumeci, Francesca,Carraro, Fabio,Naldini, Antonella,Filippi, Irene,Maga, Giovanni,Schenone, Silvia,Botta, Maurizio. "Design, synthesis, biological activity, and ADME properties of pyrazolo[3,4- d ]pyrimidines active in hypoxic human leukemia Cells: A lead optimization study". supporting information; experimental part. p. 2610 - 2626. Retrieved 2011/06/21.