TRICLOSAN METHYL ETHER

Base Information

• Chemical Name: TRICLOSAN METHYL ETHER
• CAS No.: 4640-01-1
• Molecular Formula: C13H9Cl3O2
• Molecular Weight: 303.572
• Hs Code.: 2909309090
• Mol file: 4640-01-1.mol

Synonyms:Benzene,4-chloro-1-(2,4-dichlorophenoxy)-2- methoxy-;Triclosan methyl;Benzene, 4-chloro-1-(2,4-dichlorophenoxy)-2-methoxy-;

Chemical Property of TRICLOSAN METHYL ETHER

Chemical Property:

• Appearance/Colour: colourless syrup
• Vapor Pressure: 5.18E-05mmHg at 25°C
• Melting Point: 210-217 °C
• Refractive Index: 1.588
• Boiling Point: 358.7 °C at 760 mmHg
• Flash Point: 128.5 °C
• PSA: 18.46000
• Density: 1.38 g/cm³
• LogP: 5.44770
• Storage Temp.: Refrigerator

Purity/Quality:

98%Min ^*data from raw suppliers

TriclosanMethylEther ^*data from reagent suppliers

Safty Information:

• Pictogram(s): N
• Hazard Codes: N
• Statements: 50/53
• Safety Statements: 60-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: A bactericide detected in rivers and lakes. The current lot contains 8.7% d2, 0.2% d1 and 0.002% d0.

Technology Process of TRICLOSAN METHYL ETHER

There total 5 articles about TRICLOSAN METHYL ETHER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.8%

triclosan (3380-34-5,88032-08-0) + methyl iodide (74-88-4) → 4-chloro-1-[2,4-dichlorophenoxy]-2-methoxybenzene (4640-01-1)

Guidance literature:

With sodium hydroxide; In acetone; at 20 - 40 ℃; for 4.25h; Temperature;

Reference yield:

2,4,4'-trichloro-2'-bromodiphenyl ether (300350-24-7) → 4-chloro-1-[2,4-dichlorophenoxy]-2-methoxybenzene (4640-01-1)

Guidance literature:

With hydrogenchloride; sodium methylate; copper(I) chloride; In N-methyl-acetamide; water;

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + triclosan (3380-34-5,88032-08-0) → 4-chloro-1-[2,4-dichlorophenoxy]-2-methoxybenzene (4640-01-1)

Guidance literature:

In diethyl ether;

DOI:10.1002/oms.1210200210

upstream raw materials:

diazomethane

triclosan

2,4,4'-trichloro-2'-bromodiphenyl ether

methyl iodide

Refernces

• 1、 -. "Preparation method of triclosan methyl ester". Paragraph 0027-0046. . Retrieved 2020/06/05.
• 2、 Allmyr, Mats,McLachlan, Michael S.,Sandborgh-Englund, Gunilla,Adolfsson-Erici, Margaretha. "Determination of triclosan as its pentafluorobenzoyl ester in human plasma and milk using electron capture negative ionization mass spectrometry". . p. 6542 - 6546. Retrieved 2007/10/03.