2,5-Dimethoxy-4-methylamphetamine

Base Information

• Chemical Name: 2,5-Dimethoxy-4-methylamphetamine
• CAS No.: 15588-95-1
• Deprecated CAS: 18539-33-8,26011-50-7,26011-50-7
• Molecular Formula: C12H19 N O2
• Molecular Weight: 209.288
• Hs Code.: 2922199090
• UNII: UKI9MLD5OI
• DSSTox Substance ID: DTXSID50860611
• Nikkaji Number: J14.785K
• Wikipedia: 2,5-Dimethoxy-4-methylamphetamine
• Wikidata: Q62267185
• Pharos Ligand ID: CKKF8J3PDNQD
• Metabolomics Workbench ID: 146176
• ChEMBL ID: CHEMBL8600
• Mol file: 15588-95-1.mol

Synonyms:1-(2,5-Dimethoxy-4-Methylphenyl)-2-Aminopropane;2 5 DOM;2,5 Dimethoxy 4 Methylamphetamine;2,5-Dimethoxy-4-Methylamphetamine;2,5-Dimethoxy-4-Methylamphetamine Hydrochloride, (+,-)-Isomer;2,5-Dimethoxy-4-Methylamphetamine Hydrochloride, (R)-Isomer;2,5-Dimethoxy-4-Methylamphetamine Hydrochloride, (S)-Isomer;2,5-Dimethoxy-4-Methylamphetamine, (+,-)-Isomer;2,5-Dimethoxy-4-Methylamphetamine, (R)-Isomer;2,5-Dimethoxy-4-Methylamphetamine, (S)-Isomer;2,5-Dimethoxy-4-Methylamphetamine, Hydrochloride;DOM

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of 2,5-Dimethoxy-4-methylamphetamine

Chemical Property:

• Vapor Pressure: 0.000274mmHg at 25°C
• Melting Point: 60.5-61°
• Refractive Index: 1.509
• Boiling Point: 322.7°Cat760mmHg
• PKA: 9.77±0.10(Predicted)
• Flash Point: 162.9°C
• PSA: 44.48000
• Density: 0.998g/cm³
• LogP: 2.60220
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 209.141578849
• Heavy Atom Count: 15
• Complexity: 187

Purity/Quality:

Safty Information:

• Pictogram(s): A poison by ingestion.
• Hazard Codes: A poison by ingestion.

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1OC)CC(C)N)OC
• Uses: 2,5-Dimethoxy-4-methylamphetamine (DOM, STP) DOM is an amphetamine with dose-dependent psychotomimetic and hallucinogenic effects. It potently binds and activates serotonin 5-HT2 receptors (pA2 = 7.12). DOM is classified as a Schedule I compound in the United States. This product is intended for research and forensic purposes.

Technology Process of 2,5-Dimethoxy-4-methylamphetamine

There total 8 articles about 2,5-Dimethoxy-4-methylamphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2,5-Dimethoxy-4-methyl-phenyl)-2-nitro-propen (29907-72-0) → 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (15588-95-1)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1139/v74-063

Reference yield:

1-(2,5-dimethoxy-4-methylphenyl)-2-propyl azide (609771-65-5) → 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (15588-95-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 12h; under 2068.59 Torr;

DOI:10.1016/S0957-4166(03)00438-5

Reference yield:

2,5-dimethoxy-4-methylbenzaldehyde (4925-88-6) → 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (15588-95-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium acetate / 1.) reflux, 8 h, 2.) RT, 60 h

2: LiAlH₄, H₂SO₄ / tetrahydrofuran / Ambient temperature

With ammonium acetate; lithium aluminium tetrahydride; sulfuric acid; In tetrahydrofuran;

DOI:10.1021/jm00082a014

upstream raw materials:

1-(2,5-Dimethoxy-4-methyl-phenyl)-2-nitro-propen

1-(2,5-dimethoxy-4-methylphenyl)-2-propyl azide

1-(2,5-dimethoxy-4-methylphenyl)-2-propyl tosylate

2,5-dimethoxy toluene

Downstream raw materials:

(-)-DOM

(+)-DOM

(+/-)-N-methyl DOM

1-(2,5-dimethoxy-4-methylphenyl)-2-benzamidopropane

Refernces

• 1、 Glennon, Richard A.,Raghupathi, Reva,Bartyzel, Piotr,Teitler, Milt,Leonhardt, Sigrun. "Binding of Phenylalkylamine Derivatives at 5-HT1C and 5-HT2 Serotonin Receptors: Evidence for a Lack of Selectivity". . p. 734 - 740. Retrieved 2007/10/02.