Tetrazolo[1,5-c]quinazoline

Base Information

• Chemical Name: Tetrazolo[1,5-c]quinazoline
• CAS No.: 234-77-5
• Molecular Formula: C8H5 N5
• Molecular Weight: 171.1588
• NSC Number: 127213
• UNII: 7UWV5UYI5C
• DSSTox Substance ID: DTXSID10177954
• Nikkaji Number: J2.950.297H
• Wikidata: Q83048298
• Mol file: 234-77-5.mol

Synonyms:Tetrazolo[1,5-c]quinazoline;Tetrazolo(1,5-c)quinazoline;234-77-5;Tetraazolo(1,5-c)quinazoline;7UWV5UYI5C;UNII-7UWV5UYI5C;NSC127213;NSC 127213;NSC-127213;Tetraazolo[1,5-c]quinazoline;Cambridge id 5585873;SCHEMBL8649431;{Tetrazolo[1,5-c]quinazoline};DTXSID10177954;CCG-2728;AKOS003589810

Chemical Property of Tetrazolo[1,5-c]quinazoline

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.62g/cm³
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 171.05449518
• Heavy Atom Count: 13
• Complexity: 197

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C3=NN=NN3C=N2

Technology Process of Tetrazolo[1,5-c]quinazoline

There total 4 articles about Tetrazolo[1,5-c]quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-Hydroxyquinazoline (491-36-1) → tetrazolo<1,5-c>quinazoline (234-77-5)

Guidance literature:

With sodium azide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 - 50 ℃;

DOI:10.1021/jo7020373

Reference yield: 50.0%

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) + formamide (77287-34-4,77287-35-5,60100-09-6) → tetrazolo<1,5-c>quinazoline (234-77-5)

Guidance literature:

With trimethylsilylazide; trichlorophosphate; In acetonitrile; at 180 ℃; for 0.166667h; Microwave irradiation;

DOI:10.1002/ejoc.201600317

Reference yield:

4-hydrazinoquinazoline (36075-44-2) → tetrazolo<1,5-c>quinazoline (234-77-5)

Guidance literature:

With sodium nitrite;

DOI:10.17344/acsi.2016.2464

upstream raw materials:

4-Hydroxyquinazoline

anthranilic acid

formamide

4-hydrazinoquinazoline

Downstream raw materials:

5-(2-aminophenyl)tetrazole

Refernces

• 1、 Antypenko, Oleksii,Kovalenko, Sergiy,Rasulev, Bakhtiyor,Leszczynski, Jerzy. "Synthesis of 6-N-R-tetrazolo[1,5-c]quinazolin-5(6H)-ones and their anticancer activity". . p. 638 - 645. Retrieved 2016/10/06.