Piperidine, N-(ethoxymethyl)-

Base Information

• Chemical Name: Piperidine, N-(ethoxymethyl)-
• CAS No.: 3275-13-6
• Molecular Formula: C8H17NO
• Molecular Weight: 143.229
• Hs Code.: 2933399090
• NSC Number: 507287
• UNII: ZH7LCV9KZ7
• DSSTox Substance ID: DTXSID40186418
• Nikkaji Number: J50.662A
• Wikidata: Q83057694
• Mol file: 3275-13-6.mol

Synonyms:N-(Ethoxymethyl)piperidine;PIPERIDINE, N-(ETHOXYMETHYL)-;1-(Ethoxymethyl)piperidine;N-Aethoxymethylpiperidin;3275-13-6;Piperidine, 1-(ethoxymethyl)-;N-Aethoxymethylpiperidin [German];NSC 507287;BRN 0103749;N-Aethoxymethylpiperidin [German];NSC-507287;4-20-00-00849 (Beilstein Handbook Reference);C(OCC)N1CCCCC1;ZH7LCV9KZ7;ethoxy-N-piperidinylmethane;1-(ethoxymethyl)pi-peridine;NCIOpen2_003536;WLN: T6NTJ A1O2;1-(Ethoxymethyl)piperidine #;SCHEMBL2016344;DTXSID40186418;NSC507287;Piperidine, 1-(ethoxymethyl)- (8CI);LS-115510

Chemical Property of Piperidine, N-(ethoxymethyl)-

Chemical Property:

• Vapor Pressure: 1.26mmHg at 25°C
• Boiling Point: 173.5°Cat760mmHg
• PKA: 8.84±0.10(Predicted)
• Flash Point: 47.7°C
• PSA: 12.47000
• Density: 0.906g/cm³
• LogP: 1.40420
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 143.131014166
• Heavy Atom Count: 10
• Complexity: 79.3

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOCN1CCCCC1

Technology Process of Piperidine, N-(ethoxymethyl)-

There total 2 articles about Piperidine, N-(ethoxymethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.1%

piperidine (110-89-4) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + ethanol (64-17-5) → 1-(ethoxymethyl)piperidine (3275-13-6)

Guidance literature:

With potassium carbonate; at 20 ℃; for 48h; Cooling with ice;

DOI:10.1080/00958972.2016.1269894

Reference yield:

→ 1-(ethoxymethyl)piperidine (3275-13-6)

Guidance literature:

Piperidin, C2H5OH, Paraformaldehyd;

Reference yield: 93.6%

1-(ethoxymethyl)piperidine (3275-13-6) + 2-hydroxy-5-t-butylbenzaldehyde (2725-53-3) → 5-(tert-butyl)-2-hydroxy-3-(piperidin-1-yl-methyl)benzaldehyde (297177-27-6)

Guidance literature:

In acetonitrile; for 90h; Reflux; Inert atmosphere;

DOI:10.1080/00958972.2016.1269894

upstream raw materials:

piperidine

formaldehyd

ethanol

Downstream raw materials:

4-nitro-2-(piperidin-1'-ylmethyl)phenol

1-(octylmercapto-methyl)-piperidine

N-(ethoxymethyl)diethylamine

2-piperidinomethylene-1-naphthol

Refernces

• 1、 Heaney, Harry,Papageorgiou, George,Wilkins, Robert F.. "The generation of iminium ions using chlorosilanes and their reactions with electron rich aromatic heterocycles". . p. 2941 - 2958. Retrieved 2007/10/03.
• 2、 Quintard, Jean-Paul,Elissondo, Bernard,Jousseaume, Bernard. "A Convenient Synthesis of N,N-Disubstituted Aminomethyltri-n-butylstannanes, Precursors of the Corresponding Lithium Reagents". . p. 495 - 498. Retrieved 2007/10/02.