TENIDAP

Base Information

• Chemical Name: TENIDAP
• CAS No.: 120210-48-2
• Molecular Formula: C₁₄H₉ClN₂O₃S
• Molecular Weight: 320.756
• Mol file: 120210-48-2.mol

Synonyms:1H-Indole-1-carboxamide,5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-, (Z)-; CP 66248;Tenidap

Chemical Property of TENIDAP

Chemical Property:

• Vapor Pressure: 7.42E-13mmHg at 25°C
• Melting Point: 230° (dec)
• Boiling Point: 523.9°Cat760mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 270.7°C
• PSA: 111.87000
• Density: 1.58g/cm³
• LogP: 4.01840
• Storage Temp.: Store at +4°C
• Solubility.: DMSO: soluble1mg/mL, clear (warmed)

Purity/Quality:

98%Min ^*data from raw suppliers

Tenidap ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Anti-inflammatory (osteoarthritis and rheumatoid arthritis). Tenidap is one of the nonsteroidal antiinflammatory drugs (NSAIDs). Tenidap is an NSAID that preferentially inhibits COX-1. Tenidap inhibits formation of pro-inflammatory arachidonic acid metabolites in isolated human peripheral polymorphonuclear leukocytes.

Technology Process of TENIDAP

There total 13 articles about TENIDAP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(Z)-5-chloro-3-[1-hydroxy-1-(2-thienyl)methylene]-2-oxo-1-phenoxycarbonyl-2,3-dihydroindole (255712-72-2) → tenidap (120210-48-2)

Guidance literature:

(Z)-5-chloro-3-[1-hydroxy-1-(2-thienyl)methylene]-2-oxo-1-phenoxycarbonyl-2,3-dihydroindole; With ammonium carbonate; In N,N-dimethyl-formamide; at 75 - 80 ℃; for 5h;

With hydrogenchloride; In N,N-dimethyl-formamide;

DOI:10.1007/s00706-003-0127-9

Reference yield: 80.0%

(Z)-5-chloro-3-1-hydroxy-1-(2-thienyl)methylene-2-oxo-1-phenoxycarbonyl-2,3-dihydroindole ammonium salt → tenidap (120210-48-2)

Guidance literature:

(Z)-5-chloro-3-1-hydroxy-1-(2-thienyl)methylene-2-oxo-1-phenoxycarbonyl-2,3-dihydroindole ammonium salt; With ammonium carbonate; In N,N-dimethyl-formamide; at 75 - 80 ℃; for 5h;

With hydrogenchloride; In N,N-dimethyl-formamide; at 0 - 5 ℃; for 2h;

DOI:10.1021/op990067a

Reference yield: 79.0%

2-Thiophenecarbonyl chloride (5271-67-0) + 5-chloro-2-oxo-1-phenoxycarbonyl-2,3-dihydroindole (197776-03-7) → tenidap (120210-48-2)

Guidance literature:

2-Thiophenecarbonyl chloride; 5-chloro-2-oxo-1-phenoxycarbonyl-2,3-dihydroindole; With dmap; In N,N-dimethyl-formamide;

With ammonium carbonate; In N,N-dimethyl-formamide; at 75 - 80 ℃; for 5h;

With hydrogenchloride; In water; N,N-dimethyl-formamide;

DOI:10.1007/s00706-003-0127-9

upstream raw materials:

2-Thiophenecarbonyl chloride

5-chloro-2-oxo-1-phenoxycarbonyl-2,3-dihydroindole

phenyl 5-chloro-2-[(phenoxycarbonyl)oxy]-1H-indole-1-carboxylate

(Z)-5-chloro-3-[1-hydroxy-1-(2-thienyl)methylene]-2-oxo-1-phenoxycarbonyl-2,3-dihydroindole

Refernces

• 1、 Porcs-Makkay, Marta,Volk, Balazs,Kapiller-Dezsoefi, Rita,Mezei, Tibor,Simig, Gyula. "New routes to oxindole derivatives". . p. 697 - 711. Retrieved 2007/10/03.