Moroxydine

Base Information

• Chemical Name: Moroxydine
• CAS No.: 3731-59-7
• Molecular Formula: C6H13N5O
• Molecular Weight: 171.202
• Hs Code.: 2934999090
• European Community (EC) Number: 223-093-1
• UNII: O611591WAH
• DSSTox Substance ID: DTXSID3048526
• Nikkaji Number: J9.583D
• Wikipedia: Moroxydine
• Wikidata: Q781304
• NCI Thesaurus Code: C66200
• Metabolomics Workbench ID: 123542
• Mol file: 3731-59-7.mol

Synonyms:4-morpholinocarboximidoylguanidine;Flumidine;Influmine;moroxidine;moroxydine;moroxydine monohydrochloride;N-amidino-4-morpholinecarboxamidine;SKF 8898-A;SKF-8898-A;SKF-8898A;Vironil;Virustat

Chemical Property of Moroxydine

Chemical Property:

• Appearance/Colour: WHITE TO OFF-WHITE POWDER, CRYSTALS,. CRYSTALLINE POWDER AND/OR CHUNKS
• Vapor Pressure: 0.000207mmHg at 25°C
• Melting Point: 211-214 °C(lit.)
• Refractive Index: 1.661
• Boiling Point: 327 °C at 760 mmHg
• PKA: 13.01±0.10(Predicted)
• Flash Point: 151.6 °C
• PSA: 98.22000
• Density: 1.51 g/cm³
• LogP: -0.03500
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: -1.6
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 171.11201006
• Heavy Atom Count: 12
• Complexity: 192

Purity/Quality:

99% ^*data from raw suppliers

N-carbamimidoylmorpholine-4-carboximidamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1COCCN1C(=N)N=C(N)N
• Uses: antiviral
• Therapeutic Function: Antiviral

Technology Process of Moroxydine

There total 4 articles about Moroxydine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

morpholine (110-91-8,99108-56-2) + N-Cyanoguanidine (127099-85-8,780722-26-1,461-58-5) → moroxydine (3731-59-7)

Guidance literature:

morpholine; N-Cyanoguanidine; In toluene; at 20 ℃; for 0.25h;

With hydrogenchloride; In water; toluene; for 7h;

DOI:10.1155/2017/1212609

Reference yield:

moroxydine hydrochloride (3160-91-6,7420-18-0) → moroxydine (3731-59-7)

Guidance literature:

With potassium carbonate; In water; at 20 ℃; for 0.5h;

Reference yield:

morpholin hydrochloride (10024-89-2) + N-Cyanoguanidine (127099-85-8,780722-26-1,461-58-5) → moroxydine (3731-59-7)

Guidance literature:

at 130 - 150 ℃;

DOI:10.1021/ja01523a059

upstream raw materials:

morpholin hydrochloride

N-Cyanoguanidine

morpholine

moroxydine hydrochloride

Downstream raw materials:

Morpholin-4-

4-({[2-amino-4-(morpholin-4-yl)-1,3,5-triazin-6-yl]methyl}amino)benzoic acid

ethyl {4-[{[2-amino-4-(morpholin-4-yl)-1,3,5-triazin-6-yl]methyl}amino]benzoyl}-L-glutamate

4-morpholino-1,3,5-triazin-2-amine

Refernces

• 1、 Gutierrez-Lara, Erika,Martínez-Conde, Carlos,Rosales-Ortega, Edgar,Ramírez-Espinosa, Juan José,Rivera-Leyva, Julio C.,Centurión, David,Carvajal, Karla,Ortega-Cuellar, Daniel,Estrada-Soto, Samuel,Navarrete-Vázquez, Gabriel. "Synthesis and in Vitro AMPK Activation of Cycloalkyl/Alkarylbiguanides with Robust in Vivo Antihyperglycemic Action". . . Retrieved 2018/02/28.
• 2、 Dao, Pascal,Garbay, Christiane,Chen, Huixiong. "High yielding microwave-assisted synthesis of tri-substituted 1,3,5-triazines using Pd-catalyzed aryl and heteroarylamination". scheme or table. p. 3856 - 3860. Retrieved 2012/06/30.