JNJ 31020028

Base Information

• Chemical Name: JNJ 31020028
• CAS No.: 1094873-14-9
• Molecular Formula: C34H36FN5O2
• Molecular Weight: 565.691
• Mol file: 1094873-14-9.mol

Synonyms:UNII-73F8XED6YP;

Chemical Property of JNJ 31020028

Chemical Property:

• PSA: 72.27000
• LogP: 6.25860

Purity/Quality:

99% ^*data from raw suppliers

JNJ-31020028 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: JNJ-31020028 is a brain-permeable selective antagonist of the neuropeptide Y (NPY) receptor Y2 (IC50s = 8.51, 6.03, and 6.17 nM for human, rat, and mouse receptors, respectively) with over 100-fold selectivity for Y2 over Y1, Y4, and Y5 receptors. JNJ-31020028 inhibits calcium release induced by peptide YY in a functional assay in KAN-TS cells (pKB = 8.04) and blocks NPY(13-36)-induced decreases in twitch contraction amplitude in isolated rat vas deferens (IC50 = 7.94 nM). Administration of JNJ-31020028 to rats during abstinence (20 mg/kg per day, i.p.) reverses nicotine-induced social anxiety-like behavior and increases hippocampal Y2 receptor mRNA levels. It reverses withdrawal-induced anxiety-like behavior in rats in the elevated plus maze following a single bolus dose of alcohol when administered at a dose of 15 mg/kg. In an olfactory bulbectomized rat model of depression, chronic JNJ-31020028 treatment (10 nmol per day, i.c.v.) decreases immobility time in the forced swim test but has no effect in control animals.

Technology Process of JNJ 31020028

There total 1 articles about JNJ 31020028 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(pyridin-3′-yl) benzoic acid (134363-45-4) + 2-[4-(4-amino-2-fluoro-phenyl)-piperazin-1-yl]-N,N-diethyl-2-phenyl-acetamide (935854-67-4) → JNJ-31020028 (1094873-14-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

JNJ-31020028 (1094873-14-9) → N-{4-[4-(diethylcarbamoyl-phenyl-methyl)-piperazin-1-yl]-3-fluoro-phenyl}-2-pyridin-3-yl-benzamide bis-hydrochloride

Guidance literature:

With hydrogenchloride; In diethyl ether; ethanol; at 20 ℃; for 2h;

Reference yield:

JNJ-31020028 (1094873-14-9) + maleic acid (110-16-7,26099-09-2) → N-(4-[4-(diethylcarbamoyl-phenyl-methyl)-piperazin-1-yl]-3-fluoro-phenyl)-2-pyridin-3-yl-benzamide maleate (1094873-28-5)

Guidance literature:

In ethanol; dichloromethane; for 3h; sonication;

upstream raw materials:

2-(pyridin-3′-yl) benzoic acid

2-[4-(4-amino-2-fluoro-phenyl)-piperazin-1-yl]-N,N-diethyl-2-phenyl-acetamide

Downstream raw materials:

N-(4-[4-(diethylcarbamoyl-phenyl-methyl)-piperazin-1-yl]-3-fluoro-phenyl)-2-pyridin-3-yl-benzamide maleate

(-)-JNJ-31020028

(+)-JNJ-31020028

Refernces