KU-60019

Base Information

• Chemical Name: KU-60019
• CAS No.: 925701-49-1
• Molecular Formula: C₃₀H₃₃N₃O₅S
• Molecular Weight: 547.675
• Mol file: 925701-49-1.mol

Synonyms:(2R,6S)-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide; 2-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-N-{5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl}acetamide

Chemical Property of KU-60019

Chemical Property:

• Boiling Point: 786.6 °C at 760 mmHg
• Flash Point: 429.5 °C
• PSA: 109.55000
• Density: 1.314g/cm³
• LogP: 4.32240
• Storage Temp.: -20°C
• Solubility.: ≥27.4 mg/mL in DMSO; insoluble in H2O; ≥51.2 mg/mL in EtOH

Purity/Quality:

98%,99%, ^*data from raw suppliers

KU 60019 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: KU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM in cell-free assays, 270- and 1600-fold more selective for ATM than DNA-PK and ATR,and is a highly effective radiosensitizer.
• Uses: KU-60019 has been used to block ataxia telangiectasia mutated (ATM), to study its association of with the regulation of H2AX (H2A histone family, member X) and apoptosis inducing factor (AIF)-mediated cell death.

Technology Process of KU-60019

There total 1 articles about KU-60019 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cis-2,6-dimethylmorpholine + 2-(7-amino-9H-thioxanthen-4-yl)-6-morpholin-4-yl-pyran-4-one (587871-49-6) + chloroacetyl chloride (79-04-9) → (2R,6S-rel)-2,6-dimethyl-N-[5[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide (925701-46-8,925701-49-1)

Guidance literature:

2-(7-amino-9H-thioxanthen-4-yl)-6-morpholin-4-yl-pyran-4-one; chloroacetyl chloride; With triethylamine; In N,N-dimethyl acetamide; at 20 ℃; for 1.5h;

cis-2,6-dimethylmorpholine; In N,N-dimethyl acetamide; at 20 ℃; Product distribution / selectivity;

upstream raw materials:

2-(7-amino-9H-thioxanthen-4-yl)-6-morpholin-4-yl-pyran-4-one

chloroacetyl chloride

Refernces