N1,N1,3-TRIMETHYLBUTANE-1,3-DIAMINE

Base Information

• Chemical Name: N1,N1,3-TRIMETHYLBUTANE-1,3-DIAMINE
• CAS No.: 933738-55-7
• Molecular Formula: C₇H₁₈N₂
• Molecular Weight: 130.233
• Hs Code.: 2921290000
• Mol file: 933738-55-7.mol

Synonyms:N¹,N¹,3-Trimethylbutane-1,3-diamine;LogP

Chemical Property of N1,N1,3-TRIMETHYLBUTANE-1,3-DIAMINE

Chemical Property:

• Vapor Pressure: 2.67mmHg at 25°C
• Refractive Index: 1.45
• Boiling Point: 158.1 °C at 760 mmHg
• PKA: 10.41±0.25(Predicted)
• Flash Point: 46.4 °C
• PSA: 29.26000
• Density: 0.839 g/cm³
• LogP: 1.37570
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

N1,N1,3-Trimethylbutane-1,3-diamine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N1,N1,3-TRIMETHYLBUTANE-1,3-DIAMINE

There total 4 articles about N1,N1,3-TRIMETHYLBUTANE-1,3-DIAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-azido-N,N,3-trimethylbutanamide (1226913-36-5) → N,N-3-trimethylbutane-1,3-diamine (933738-55-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 70 ℃; for 8h;

DOI:10.1016/j.bmcl.2011.04.084

Reference yield:

3-azido-3-methylbutanoyl chloride (1226913-35-4) → N,N-3-trimethylbutane-1,3-diamine (933738-55-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 2 h / Cooling with ice

2: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 70 °C

With lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2011.04.084

Reference yield:

3-Methylbutenoic acid (541-47-9) → N,N-3-trimethylbutane-1,3-diamine (933738-55-7)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium azide; acetic acid / water / 48 h / 95 °C

2: thionyl chloride / 1,2-dichloro-ethane / 4 h / Reflux

3: dichloromethane / 2 h / Cooling with ice

4: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 70 °C

With lithium aluminium tetrahydride; thionyl chloride; sodium azide; acetic acid; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane;

DOI:10.1016/j.bmcl.2011.04.084

upstream raw materials:

3-azido-3-methylbutanoyl chloride

3-azido-N,N,3-trimethylbutanamide

3-Methylbutenoic acid

3-azido-3-methylbutanoic acid

Downstream raw materials:

C₁₆H₂₇N₂O₂⁽¹⁺⁾*I^(1-)

3-(((benzyloxy)carbonyl)amino)-N-(2-butoxyethyl)-N,N,3-trimethylbutan-1-aminium chloride

3-(((benzyloxy)carbonyl)amino)-N-(2-(hexyloxy)ethyl)-N,N,3-trimethylbutan-1-aminium 4-methylbenzenesulfonate

3-(((benzyloxy)carbonyl)amino)-N-(2-methoxyethyl)-N,N,3-trimethylbutan-1-aminium chloride

Refernces

• 1、 Low, Eddy,Kim, Bum,Francavilla, Charles,Shiau, Timothy P.,Turtle, Eric D.,O'Mahony, Donogh J.R.,Alvarez, Nichole,Houchin, Ashley,Xu, Ping,Zuck, Meghan,Celeri, Chris,Anderson, Mark B.,Najafi, Ramin,Jain, Rakesh K.. "Structure stability/activity relationships of sulfone stabilized N,N-dichloroamines". . p. 3682 - 3685. Retrieved 2011/08/06.