5-bromo-6-chloro-indole

Base Information

• Chemical Name: 5-bromo-6-chloro-indole
• CAS No.: 122531-09-3
• Molecular Formula: C8H5BrClN
• Molecular Weight: 230.491
• Hs Code.: 2933990090
• Mol file: 122531-09-3.mol

Synonyms:5-Bromo-6-chloro-1H-indole;

Chemical Property of 5-bromo-6-chloro-indole

Chemical Property:

• Boiling Point: 357.991 °C at 760 mmHg
• PKA: 15.14±0.30(Predicted)
• Flash Point: 170.307 °C
• PSA: 15.79000
• Density: 1.773 g/cm³
• LogP: 3.58380
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-6-chloro-1H-indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-bromo-6-chloro-indole

There total 2 articles about 5-bromo-6-chloro-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

→ 5-bromo-6-chloro-1H-indole (122531-09-3)

Guidance literature:

Reference yield: 15.0%

1-bromo-2-chloro-4-nitrobenzene (29682-39-1) + vinyl magnesium bromide (1826-67-1) → 5-bromo-6-chloro-1H-indole (122531-09-3)

Guidance literature:

In tetrahydrofuran; at -40 ℃; for 1h; Inert atmosphere;

Reference yield: 86.0%

5-bromo-6-chloro-1H-indole (122531-09-3) + (4-ethoxyphenyl)boronic acid (22237-13-4) → 6-chloro-5-(4-ethoxyphenyl)-1H-indole (1467060-56-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; for 16h; Inert atmosphere; Reflux;

upstream raw materials:

1-bromo-2-chloro-4-nitrobenzene

vinyl magnesium bromide

Downstream raw materials:

6-chloro-5-(4-ethoxyphenyl)-1H-indole

6-chloro-5-(4-methoxy-phenyl)-1H-indole

6-chloro-5-(4-(2-hydroxyethoxy)phenyl)-1H-indole-3-carboxylic acid

5-{4-[(1-acetylazetidin-3-yl)methoxy]phenyl}-6-chloro-1H-indole-3-carbaldehyde

Refernces

• 1、 -. "GPR119 AGONIST". Page/Page column 39. . Retrieved 2012/07/27.