2-Bromomethyl-oxetane

Base Information

• Chemical Name: 2-Bromomethyl-oxetane
• CAS No.: 939759-23-6
• Molecular Formula: C4H7BrO
• Molecular Weight: 151.003
• Hs Code.: 2932999099
• Mol file: 939759-23-6.mol

Synonyms:2-(bromomethyl)oxetane;

Chemical Property of 2-Bromomethyl-oxetane

Chemical Property:

• Vapor Pressure: 3.41mmHg at 25°C
• Refractive Index: 1.49
• Boiling Point: 158.4 °C at 760 mmHg
• Flash Point: 60.7 °C
• PSA: 9.23000
• Density: 1.568 g/cm³
• LogP: 1.17020
• Storage Temp.: -20°C
• Sensitive.: Moisture Sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Bromomethyl)oxetane 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromomethyl-oxetane

There total 1 articles about 2-Bromomethyl-oxetane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(oxetan-2-yl)methyl 4-methylbenzene-1-sulfonate (115845-51-7) → racemic 2-(bromomethyl)oxetane (939759-23-6)

Guidance literature:

With potassium bromide; In 2,2'-[1,2-ethanediylbis(oxy)]bisethanol; at 200 ℃;

Reference yield: 67.0%

tert-butyl N-[4-(methylamino)cyclohexyl]carbamate (919834-80-3) + racemic 2-(bromomethyl)oxetane (939759-23-6) → tert-butyl ((1,4-trans)-4-(methyl(oxetan-2-ylmethyl)amino)cyclohexyl)carbamate

Guidance literature:

With triethylamine; In acetonitrile; at 65 ℃; for 23h;

Reference yield: 63.9%

racemic 2-(bromomethyl)oxetane (939759-23-6) + C23H17FN4O2 → N-[3-(2-Chloro-5-fluorophenyl)-6-[(oxetan-2-yl)methyl]-1-oxo-2,3-dihydro-1H-isoindol-4-yl]-3-fluoro-5-(trifluoromethyl)benzamide

Guidance literature:

With 2,6-dimethylpyridine; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; 1,1,1,3,3,3-hexamethyl-disilazane; 4,4'-di-tert-butyl-2,2'-bipyridine; nickel dichloride; In 1,4-dioxane; for 3h; Inert atmosphere; Irradiation;

upstream raw materials:

(oxetan-2-yl)methyl 4-methylbenzene-1-sulfonate

Downstream raw materials:

9-(2,4-dimethoxybenzyl)-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7-(oxetan-2-ylmethyl)-7,9-dihydro-8H-purin-8-one

Refernces