(5-Chloro-1H-indazol-3-yl)-methanol ,97%

Base Information

• Chemical Name: (5-Chloro-1H-indazol-3-yl)-methanol ,97%
• CAS No.: 102735-90-0
• Molecular Formula: C8H7ClN2O
• Molecular Weight: 182.607
• Hs Code.: 29339900
• Mol file: 102735-90-0.mol

Synonyms:1H-Indazole-3-methanol, 5-chloro-;

Chemical Property of (5-Chloro-1H-indazol-3-yl)-methanol ,97%

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.725
• Boiling Point: 412.438 °C at 760 mmHg
• PKA: 12.81±0.40(Predicted)
• Flash Point: 203.235 °C
• PSA: 48.91000
• Density: 1.511 g/cm³
• LogP: 1.70860
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(5-Chloro-1H-indazol-3-yl)methanol 95+% ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22
• Safety Statements: 24/25-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5-Chloro-1H-indazol-3-yl)-methanol ,97%

There total 3 articles about (5-Chloro-1H-indazol-3-yl)-methanol ,97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

5-chloro-1H-indazole-3-carboxylic acid (1077-95-8) → 5-chloro-3-(hydroxymethyl)indazole (102735-90-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 4h; Heating;

DOI:10.1021/ja00274a043

Reference yield: 11.0%

methyl 5-chloro-1H-indazole-3-carboxylate (1079-46-5) → 5-chloro-3-(hydroxymethyl)indazole (102735-90-0)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at -10 - 20 ℃;

Reference yield:

5-chloroindole 2,3-dione (17630-76-1) → 5-chloro-3-(hydroxymethyl)indazole (102735-90-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / water / 1 h / 50 °C

1.2: 1 h / Cooling with ice

1.3: 20 °C

2.1: sulfuric acid / 3 h / Reflux

3.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / -10 - 20 °C

With sulfuric acid; diisobutylaluminium hydride; sodium hydroxide; In tetrahydrofuran; water; toluene;

upstream raw materials:

5-chloro-1H-indazole-3-carboxylic acid

5-chloroindole 2,3-dione

methyl 5-chloro-1H-indazole-3-carboxylate

Downstream raw materials:

5-chloro-1H-indazole-3-carbaldehyde

Refernces

• 1、 Buechi, George,Lee, Gary C. M.,Yang, David,Tannenbaum, Steven R.. "Direct Acting, Highly Mutagenic, α-Hydroxy N-Nitrosamines from 4-Chloroindoles". . p. 4115 - 4119. Retrieved 2007/10/02.