(2-Chloro-4-methoxyphenyl)acetonitrile

Base Information

• Chemical Name: (2-Chloro-4-methoxyphenyl)acetonitrile
• CAS No.: 170737-93-6
• Molecular Formula: C9H8ClNO
• Molecular Weight: 181.62
• Hs Code.: 2926909090
• Mol file: 170737-93-6.mol

Synonyms:2-(2-Chloro-4-methoxyphenyl)acetonitrile;

Chemical Property of (2-Chloro-4-methoxyphenyl)acetonitrile

Chemical Property:

• Appearance/Colour: White or dark brown powder
• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 42-44 °C
• Refractive Index: 1.536
• Boiling Point: 300.749 °C at 760 mmHg
• Flash Point: 135.689 °C
• PSA: 33.02000
• Density: 1.198 g/cm³
• LogP: 2.41468
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Insoluble in water.

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Chloro-4-methoxyphenyl)acetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi; T
• Hazard Codes: Xi,T
• Statements: 20/21/22-36/37/38
• Safety Statements: 9-26-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Chloro-4-methoxyphenylacetonitrile is used as a raw material and an intermediate in organic synthesis.

Technology Process of (2-Chloro-4-methoxyphenyl)acetonitrile

There total 4 articles about (2-Chloro-4-methoxyphenyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-4-methoxybenzyl bromide (54788-17-9) → 2-chloro-4-methoxyphenylacetonitrile (170737-93-6)

Guidance literature:

With tetra(n-butyl)ammonium hydrogen sulfate; In dichloromethane; water;

Reference yield:

2-chloro-4-methoxybenzyl bromide (54788-17-9) + tetraethylammoniumcyanide (13435-20-6) → 2-chloro-4-methoxyphenylacetonitrile (170737-93-6)

Guidance literature:

In dichloromethane; at 20 ℃; for 2h;

Reference yield:

2-chloro-4-methoxybenzyl chloride (101080-63-1) + sodium cyanide (143-33-9,25596-52-5) → 2-chloro-4-methoxyphenylacetonitrile (170737-93-6)

Guidance literature:

In dimethyl sulfoxide; at 20 ℃;

upstream raw materials:

2-chloro-4-methoxybenzyl bromide

tetraethylammoniumcyanide

2-chloro-4-methoxybenzyl chloride

sodium cyanide

Downstream raw materials:

methyl 4-(2-chloro-4-methoxyphenyl)-2-methyl-3-oxobutanoate

3-(2-chloro-4-methoxyphenyl)-N-(1-ethylpropyl)-2,5,6-trimethylpyrazolo[1,5-a]pyrimidin-7-amine

5-(2-chloro-4-methoxyphenyl)-N-(1-ethylpropyl)-6-methyl-2,3-dihydrofuro[3,2-d]pyrazolo[1,5-a]pyrimidin-9-amine

(1-ethyl-propyl)-[3-(4-methoxy-2-chlorophenyl)-2-methyl-6,7-dihydro-5H-1,4,8a-triaza-s-indacen-8-yl]-amine

Refernces

• 1、 -. "THIENOPYRIDINE-PHENYLACET AMIDES AND THEIR DERIVATIVES USEFUL AS NEW ANTI-ANGIOGENIC AGENTS". Page/Page column 68-69. . Retrieved 2010/02/11.
• 2、 -. "1-H-3-aryl-pyrrolidine-2, 4-dione derivatives as pest-control agents". . . Retrieved 2008/06/13.