2-Biphenylcarbonitrile

Base Information

• Chemical Name: 2-Biphenylcarbonitrile
• CAS No.: 27104-67-2
• Molecular Formula: C15H14N2
• Molecular Weight: 222.29
• Mol file: 27104-67-2.mol

Synonyms:2-(4-Dimethylaminophenyl)benzonitrile;4'-(Dimethylamino)biphenyl-2-carbonitrile;4'-(Dimethylamino)-1,1'-biphenyl-2-carbonitrile;

Chemical Property of 2-Biphenylcarbonitrile

Chemical Property:

• Melting Point: 106-107℃ (ligroine ethyl acetate )
• Boiling Point: 403.9 °C at 760 mmHg
• PKA: 4.32±0.12(Predicted)
• Flash Point: 179.8 °C
• PSA: 23.79000
• Density: 1.11 g/cm³
• LogP: 3.22528

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Biphenylcarbonitrile

There total 4 articles about 2-Biphenylcarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

o-cyanobromobenzene (2042-37-7) + 4-N,N-dimethylaminophenyl magnesium chloride (108949-55-9) → 4-(N,N-dimethylamino)-2'-carbonitrile-1,1'-biphenyl (27104-67-2)

Guidance literature:

4-N,N-dimethylaminophenyl magnesium chloride; With N,N,N,N,-tetramethylethylenediamine; zinc(II) chloride; In tetrahydrofuran; at 80 ℃; for 0.25h; microwave irradiation;

o-cyanobromobenzene; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 120 ℃; for 0.0333333h; microwave irradiation;

DOI:10.1016/j.tet.2005.09.022

Reference yield: 70.0%

o-cyanobromobenzene (2042-37-7) + bis[4-(dimethylamino)phenyl]zinc → 4-(N,N-dimethylamino)-2'-carbonitrile-1,1'-biphenyl (27104-67-2)

Guidance literature:

With dichloro{bis[1-(dicyclohexylphosphanyl)piperidine]}palladium(II); In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 100 ℃; for 0.0833333h; In air;

DOI:10.1002/chem.201001201

Reference yield:

o-cyanobromobenzene (2042-37-7) + (4-(N,N-dimethylamino)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (171364-78-6) → 4-(N,N-dimethylamino)-2'-carbonitrile-1,1'-biphenyl (27104-67-2)

Guidance literature:

With palladium diacetate; cesium fluoride; In tetrahydrofuran; 1,4-dioxane; at 100 ℃; for 20h;

DOI:10.1021/ol048303b

upstream raw materials:

o-cyanobromobenzene

(4-(N,N-dimethylamino)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

4-N,N-dimethylaminophenyl magnesium chloride

4-chloro-N,N-dimethylaniline

Refernces

• 1、 Mutule, Ilga,Suna, Edgars. "Arylzinc species by microwave assisted Grignard formation-transmetallation sequence: Application in the Negishi coupling". . p. 11168 - 11176. Retrieved 2007/10/03.