(5,6-Dimethoxypyridin-2-yl)methanamine

Base Information

• Chemical Name: (5,6-Dimethoxypyridin-2-yl)methanamine
• CAS No.: 1112850-40-4
• Molecular Formula: C8H12N2O2
• Molecular Weight: 168.1931
• Hs Code.: 2933399090
• Mol file: 1112850-40-4.mol

Synonyms:(5,6-Dimethoxy-2-pyridyl)methanamine;

Chemical Property of (5,6-Dimethoxypyridin-2-yl)methanamine

Chemical Property:

• Boiling Point: 251.832 °C at 760 mmHg
• Flash Point: 106.104 °C
• PSA: 57.37000
• Density: 1.116 g/cm³
• LogP: 1.25780
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(5,6-Dimethoxypyridin-2-yl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5,6-Dimethoxypyridin-2-yl)methanamine

There total 2 articles about (5,6-Dimethoxypyridin-2-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5,6-dimethoxypyridine-2-carbonitrile (1112851-50-9) → (5,6-dimethoxypyridin-2-yl)methanamine (1112850-40-4)

Guidance literature:

With hydrogenchloride; 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol; water; at 25 ℃; for 1.5h;

DOI:10.1002/cmdc.201300447

Reference yield:

2,3-dimethoxy-6-iodo-pyridine (321535-23-3,1138444-04-8) → (5,6-dimethoxypyridin-2-yl)methanamine (1112850-40-4)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation

2: hydrogenchloride; hydrogen; 10 wt% Pd(OH)2 on carbon / water; methanol / 1.5 h / 25 °C

With hydrogenchloride; 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201300447

Reference yield: 75.0%

(5,6-dimethoxypyridin-2-yl)methanamine (1112850-40-4) + potassium 5'-methyl-5-(1,3-thiazol-2-yl)-2,3'-bipyridine-4-carboxylate (1224846-11-0) → N-[(5,6-dimethoxypyridin-2-yl)methyl]-5'-methyl-5-(1,3-thiazol-2-yl)-2,3'-bipyridine-4-carboxamide (1224846-01-8)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 65 ℃; for 2h;

upstream raw materials:

5,6-dimethoxypyridine-2-carbonitrile

2,3-dimethoxy-6-iodo-pyridine

Downstream raw materials:

2-(2-fluorophenyl)-5-(5-methylpyridin-3-yl)nicotinic acid (5.6-dimethoxypyridin-2-ylmethyl)amide

2-(3-fluorophenyl)-5-(5-methylpyridin-3-yl)nicotinic acid (5,6-dimethoxypyridin-2-ylmethyl)amide

C₂₆H₂₄N₄O₃

N-[(5,6-dimethoxypyridin-2-yl)methyl]-5'-methyl-5-(1,3-thiazol-2-yl)-2,3'-bipyridine-4-carboxamide

Refernces

• 1、 -. "TRIPYRIDYL CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS". Page/Page column 17-18. . Retrieved 2010/03/02.
• 2、 -. "PYRIDAZINE CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS". Page/Page column 45-46. . Retrieved 2010/05/14.