Midodrine hydrochloride

Base Information

• Chemical Name: Midodrine hydrochloride
• CAS No.: 3092-17-9
• Molecular Formula: C12H18N2O4^.HCl
• Molecular Weight: 290.74
• Hs Code.: 29242990
• Mol file: 3092-17-9.mol

Synonyms:(+/-)-1-(2,5-Dimethoxyphenyl)-2-glycinamidoethanol hydrochloride;N-[2-(2,5-Dimethoxyphenyl)-2-hydroxyethyl]glycinamide hydrochloride (1:1);2-Amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)acetamide monohydrochloride;Acetamide, 2-amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)-, monohydrochloride;Metligene;Alphamine;

Chemical Property of Midodrine hydrochloride

Chemical Property:

• Appearance/Colour: Crystalline Solid
• Melting Point: 192-193 °C
• Boiling Point: 529.9 °C at 760 mmHg
• Flash Point: 274.3 °C
• PSA: 93.81000
• LogP: 1.70530
• Storage Temp.: -20?C Freezer

Purity/Quality:

97% ^*data from raw suppliers

Midodrine, Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: morphine antagonist A phenylalkanolamine derivative which has been found to be effective in treating hypertensive conditions due to their long lasting blood pressure increasing effects
• Therapeutic Function: Peripheral vasotonic, Antihypotensive
• Clinical Use: Treatment of orthostatic hypotension, including dialysis related hypotension
• Drug interactions: Potentially hazardous interactions with other drugs Adrenergic neurone blockers: midodrine antagonises hypotensive effect. Anaesthetics: risk of arrhythmias if given with volatile anaesthetics. Antidepressants: risk of arrhythmias and hypertension if given with tricyclic antidepressants, MAOIs and moclobemide. Antihypertensives: antagonise hypertensive effect of midodrine; risk of severe hypertension if given with beta-blockers. Dopaminergics: avoid with rasagiline and selegiline. Other drugs which increase blood pressure: enhanced hypertensive effect.

Technology Process of Midodrine hydrochloride

There total 22 articles about Midodrine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

midodrine (42794-76-3,133163-25-4,133267-39-7,97476-58-9) → midodrine hydrochloride (133163-28-7,3092-17-9,43218-56-0)

Guidance literature:

With hydrogenchloride; In ethanol; isopropyl alcohol;

Reference yield: 93.0%

2-Amino-N-[(S)-2-(2,5-dimethoxy-phenyl)-2-((1R,2R,4S,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.02,6]dec-4-yloxy)-ethyl]-acetamide → <2S-(2α,3aα,4β,7β,7aα)>-2-Methoxy- (113775-57-8) + (S)-2-Amino-N-<2-(2,5-dimethoxyphenyl)-2-hydroxyethyl>-acetamid-hydrochlorid (133163-28-7,3092-17-9,43218-56-0)

Guidance literature:

With hydrogenchloride; In methanol; diethyl ether; at 0 ℃; for 0.0166667h;

DOI:10.1007/bf00807396

Reference yield: 93.0%

2-Amino-N-[(R)-2-(2,5-dimethoxy-phenyl)-2-((1R,2R,4S,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.02,6]dec-4-yloxy)-ethyl]-acetamide → <2S-(2α,3aα,4β,7β,7aα)>-2-Methoxy- (113775-57-8) + (R)-2-Amino-N-<2-(2,5-dimethoxyphenyl)-2-hydroxyethyl>-acetamid-hydrochlorid (133163-28-7,3092-17-9,43218-56-0)

Guidance literature:

With hydrogenchloride; In methanol; diethyl ether; at 0 ℃; for 0.0166667h;

DOI:10.1007/bf00807396

upstream raw materials:

midodrine

2-azido-N-(β-hydroxy-2',5'-dimethoxyphenethyl)acetamide

BOC-glycine

desglymidodrine

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF MIDODRINE, PHARMACEUTICALLY-ACCEPTABLE SALTS THEREOF AND INTERMEDIATES". Page 9-10. . Retrieved 2010/02/08.
• 2、 -. "Process for the synthesis of (+) 2-amino-n-{2, (2,5-dimethoxy phenyl)-2-hydroxyethyl} acetamide monohydrochloride". Page 3; 4. . Retrieved 2008/06/13.