1-bromo-9H-carbazole

Base Information

• Chemical Name: 1-bromo-9H-carbazole
• CAS No.: 16807-11-7
• Molecular Formula: C12H8BrN
• Molecular Weight: 246.106
• Hs Code.: 2933990090
• European Community (EC) Number: 810-961-5
• Nikkaji Number: J1.715.549K
• ChEMBL ID: CHEMBL5085077
• Mol file: 16807-11-7.mol

Synonyms:9H-Carbazole, 1-bromo-; 1-bromo-9H-carbazole; 1-Bromocarbazole

Chemical Property of 1-bromo-9H-carbazole

Chemical Property:

• Melting Point: 123-124℃ (acetic acid )
• Boiling Point: 409.2±18.0 °C(Predicted)
• PKA: 16.14±0.30(Predicted)
• PSA: 15.79000
• Density: 1.617±0.06 g/cm3(Predicted)
• LogP: 4.08360
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 0
• Exact Mass: 244.98401
• Heavy Atom Count: 14
• Complexity: 218

Purity/Quality:

99.0% ^*data from raw suppliers

1-Bromo-9H-carbazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C3=C(N2)C(=CC=C3)Br
• Uses: 1-Bromo-9H-carbazole is a useful research chemical, mainly used as a pharmaceutical intermediate and an intermediate in organic synthesis.

Technology Process of 1-bromo-9H-carbazole

There total 23 articles about 1-bromo-9H-carbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

9H-carbazole (86-74-8,105184-46-1,97960-57-1) → 1-bromo-9H-carbazole (16807-11-7)

Guidance literature:

With N-Bromosuccinimide; In toluene; at 20 ℃; for 0.5h; Reagent/catalyst; Temperature; Solvent;

Reference yield: 75.0%

(3-bromo-2'-iodo-biphenyl-2-yl)-pyrrolidin-1-yl-diazene → 1-bromo-9H-carbazole (16807-11-7)

Guidance literature:

(3-bromo-2'-iodo-biphenyl-2-yl)-pyrrolidin-1-yl-diazene; With TurboGrignard; In tetrahydrofuran; at -40 ℃; for 1h;

In tetrahydrofuran; at 55 ℃; for 2h;

DOI:10.1021/ol0505454

Reference yield: 73.0%

2-[(2-bromo-phenyl)-phenyl-amino]-isoindole-1,3-dione (262606-95-1) → 1-bromo-9H-carbazole (16807-11-7)

Guidance literature:

With aluminium trichloride; In benzene; at 20 ℃; for 17h;

DOI:10.1021/jo016124r

upstream raw materials:

8-bromo-2,3,4,9-tetrahydro-1H-carbazole

9H-carbazole

2-[(2-bromo-phenyl)-phenyl-amino]-isoindole-1,3-dione

2,6-dibromoaniline

Downstream raw materials:

1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-9H-carbazole

(9-phenyl-9H-carbazole-1-yl)boronic acid

Refernces

• 1、 -. "Halogenated method of aromatic compound". Paragraph 0189-0194; 0230-0232; 0238. . Retrieved 2021/11/10.
• 2、 -. "ORGANOMETALLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME". Paragraph 0257-0259. . Retrieved 2017/02/24.