1-DIMETHYLAMINO-2-METHYL-2-AMINOPROPANE

Base Information

• Chemical Name: 1-DIMETHYLAMINO-2-METHYL-2-AMINOPROPANE
• CAS No.: 89379-40-8
• Molecular Formula: C6H16N2
• Molecular Weight: 116.2046
• Hs Code.: 2921290000
• Mol file: 89379-40-8.mol

Synonyms:2,N1,N1-Trimethylpropane-1,2-diamine;NSC 17718;

Chemical Property of 1-DIMETHYLAMINO-2-METHYL-2-AMINOPROPANE

Chemical Property:

• Vapor Pressure: 11.8mmHg at 25°C
• Refractive Index: 1.447
• Boiling Point: 126.2 °C at 760 mmHg
• Flash Point: 26.5 °C
• PSA: 29.26000
• Density: 0.838 g/cm³
• LogP: 0.98560

Purity/Quality:

96% 1H NMR ^*data from raw suppliers

1-DIMETHYLAMINO-2-METHYL-2-AMINOPROPANE 95.00% ^*data from reagent suppliers

Safty Information:

• Statements: 34
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2-Amino-2-methylpropyl)dimethylamine is used as a reactant in the preparation and structure activity relationships of angular benzophenazine dual topoisomerase I and topoisomerase II inhibitors as anticancer agents.

Technology Process of 1-DIMETHYLAMINO-2-METHYL-2-AMINOPROPANE

There total 4 articles about 1-DIMETHYLAMINO-2-METHYL-2-AMINOPROPANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-Dimethylamino-2-methyl-2-nitro-propan (19155-54-5) → 1-dimethylamino-2-methyl-2-aminopropane (89379-40-8)

Guidance literature:

N,N-2-trimethyl-2-nitropropanamine; With hydrogenchloride; In water; for 0.0333333h; Cooling with ice;

With zinc; In water; at 20 ℃;

Reference yield: 58.0%

2-Amino-N',N'-dimethylisobutyramid (62983-26-0) → 1-dimethylamino-2-methyl-2-aminopropane (89379-40-8)

Guidance literature:

2-Amino-N',N'-dimethylisobutyramid; With lithium aluminium tetrahydride; In tetrahydrofuran; for 16h; Heating / reflux;

With methanol; magnesium sulfate; In tetrahydrofuran;

Reference yield:

dimethyl-(β-nitro-isobutyl)-amine; hydrochloride (91447-49-3) → 1-dimethylamino-2-methyl-2-aminopropane (89379-40-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In water;

DOI:10.1248/cpb.12.946

upstream raw materials:

1-Dimethylamino-2-methyl-2-nitro-propan

dimethyl-(β-nitro-isobutyl)-amine; hydrochloride

2-Amino-N',N'-dimethylisobutyramid

Downstream raw materials:

3-Cyclohexyl-5-ethoxy-1,3-dihydro-1-[2-methoxy-4-[N-(2-dimethylamino-1,1-dimethylethyl)carbamoyl]benzyl]-2H-benzimidazol-2-one

Refernces

• 1、 -. "AMIDOPYRAZOLE DERIVATIVE". Page/Page column 126-127. . Retrieved 2010/11/23.
• 2、 TSUJI,UEDA. "SYNTHESES OF 2-GUANIDINO-2-METHYLPROPYLAMINE DERIVATIVES.". . p. 946 - 950. Retrieved 2007/10/04.