5-broMo-4-chloropyridine-2-carboxylic acid

Base Information

• Chemical Name: 5-broMo-4-chloropyridine-2-carboxylic acid
• CAS No.: 1060802-25-6
• Molecular Formula: C6H3BrClNO2
• Molecular Weight: 236.45
• Hs Code.: 2933399090
• Mol file: 1060802-25-6.mol

Synonyms:5-Bromo-4-chloropicolinic acid;5-bromo-4-chloro-2-pyridinecarboxylic acid;QC-8311;5-bromo-4-chloro-pyridine-2-carboxylic acid;

Chemical Property of 5-broMo-4-chloropyridine-2-carboxylic acid

Chemical Property:

• Boiling Point: 341.5±42.0 °C(Predicted)
• PKA: 3.04±0.10(Predicted)
• PSA: 50.19000
• Density: 1.917±0.06 g/cm3(Predicted)
• LogP: 2.19570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromo-4-chloropicolinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-broMo-4-chloropyridine-2-carboxylic acid

There total 5 articles about 5-broMo-4-chloropyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-chloro-5-bromo-2-hydroxymethylpyridine (103971-44-4) → 5-bromo-4-chloropicolinic acid (1060802-25-6)

Guidance literature:

4-chloro-5-bromo-2-hydroxymethylpyridine; With potassium permanganate; sodium carbonate; In water; for 2h;

pH=4; Acidic aqueous solution;

Reference yield:

5-bromo-2-methylpyridine (3430-13-5) → 5-bromo-4-chloropicolinic acid (1060802-25-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: urea hydrogen peroxide adduct; trifluoroacetic anhydride / dichloromethane / 12 h / 0 - 25 °C

2.1: sulfuric acid; nitric acid / 12 h / 0 - 80 °C

3.1: trichlorophosphate / dichloromethane / 0 - 25 °C

4.1: trifluoroacetic anhydride / dichloromethane / 12 h / 0 - 25 °C

5.1: potassium permanganate; sodium carbonate / water / 2 h

5.2: pH 4 / Acidic aqueous solution

With potassium permanganate; sulfuric acid; nitric acid; urea hydrogen peroxide adduct; sodium carbonate; trifluoroacetic anhydride; trichlorophosphate; In dichloromethane; water;

Reference yield:

5-bromo-2-methyl-pyridine-N-oxide (31181-64-3) → 5-bromo-4-chloropicolinic acid (1060802-25-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sulfuric acid; nitric acid / 12 h / 0 - 80 °C

2.1: trichlorophosphate / dichloromethane / 0 - 25 °C

3.1: trifluoroacetic anhydride / dichloromethane / 12 h / 0 - 25 °C

4.1: potassium permanganate; sodium carbonate / water / 2 h

4.2: pH 4 / Acidic aqueous solution

With potassium permanganate; sulfuric acid; nitric acid; sodium carbonate; trifluoroacetic anhydride; trichlorophosphate; In dichloromethane; water;

upstream raw materials:

5-bromo-2-methylpyridine

4-chloro-5-bromo-2-hydroxymethylpyridine

5-bromo-2-methyl-pyridine-N-oxide

5-bromo-2-methyl-4-nitropyridine 1-oxide

Refernces