4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER

Base Information

• Chemical Name: 4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER
• CAS No.: 1015433-96-1
• Molecular Formula: C8H5F2NO4
• Molecular Weight: 217.129
• Hs Code.: 2916399090
• Mol file: 1015433-96-1.mol

Synonyms:METHYL 4,5-DIFLUORO-2-NITROBENZOATE;methyl 3,4-difluoro-6-nitro benzoate;

Chemical Property of 4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER

Chemical Property:

• Boiling Point: 288℃
• Flash Point: 128℃
• PSA: 72.12000
• Density: 1.471
• LogP: 2.18280
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl4,5-Difluoro-2-nitrobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER

There total 3 articles about 4,5-DIFLUORO-2-NITROBENZOIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methanol (67-56-1) + 4,5-difluoro-2-nitrobenzoic acid (20372-63-8) → methyl 4,5-difluoro-2-nitrobenzoate (1015433-96-1)

Guidance literature:

With sulfuric acid; for 48h; Heating / reflux;

Reference yield:

4,5-difluoro-2-nitrobenzoic acid (20372-63-8) → methyl 4,5-difluoro-2-nitrobenzoate (1015433-96-1)

Guidance literature:

4,5-difluoro-2-nitrobenzoic acid; With thionyl chloride; for 17h; Heating / reflux;

With triethylamine; In methanol; for 2h;

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + methanol (67-56-1) + 4,5-difluoro-2-nitrobenzoic acid (20372-63-8) → methyl 4,5-difluoro-2-nitrobenzoate (1015433-96-1)

Guidance literature:

In diethyl ether; ethyl acetate; at 0 ℃; for 0.166667h;

upstream raw materials:

methanol

4,5-difluoro-2-nitrobenzoic acid

diazomethane

Downstream raw materials:

2-amino-4,5-difluoro-benzoic acid,methyl ester

C₉H₉FN₂O₄

Refernces

• 1、 -. "VIRAL POLYMERASE INHIBITORS". Page/Page column 63. . Retrieved 2010/11/28.