Imidazole-1-sulfonyl azide hydrochloride

Base Information

• Chemical Name: Imidazole-1-sulfonyl azide hydrochloride
• CAS No.: 952234-36-5
• Molecular Formula: C₃H₃N₅O₂S*(x)ClH
• Molecular Weight: 210
• Hs Code.: 2933299090
• Mol file: 952234-36-5.mol

Synonyms:Imidazole-1-sulfonyl azide hydrochloride;

Chemical Property of Imidazole-1-sulfonyl azide hydrochloride

Chemical Property:

• Melting Point: 102-104 oC
• PSA: 110.09000
• LogP: 1.62186
• Storage Temp.: 2-8°C
• Solubility.: Methanol (Slightly), Water (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

1H-Imidazole-1-sulfonylAzideHydrochlorideSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Imidazole-1-sulfonyl azide hydrochloride

There total 3 articles about Imidazole-1-sulfonyl azide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1H-imidazole (288-32-4) → imidazole-1-sulfonyl azide hydrochloride (952234-36-5)

Guidance literature:

1H-imidazole; With sodium azide; sulfuryl dichloride; In acetonitrile; for 5h; Cooling with ice;

With hydrogenchloride; acetyl chloride; In ethanol; Cooling with ice;

DOI:10.1016/j.bmc.2015.11.011

Reference yield: 76.0%

1H-imidazole (288-32-4) → imidazole-1-sulfonyl azide hydrochloride (952234-36-5)

Guidance literature:

1H-imidazole; With sodium azide; sulfuryl dichloride; In acetonitrile; at 20 ℃; for 3h;

With hydrogenchloride; acetyl chloride; In ethanol;

DOI:10.1002/chem.202100250

Reference yield:

imidazole-1-sulfonyl azide hydrochloride (952234-37-6) → imidazole-1-sulfonyl azide hydrochloride (952234-36-5)

Guidance literature:

With hydrogenchloride; ethanol; acetyl chloride; Cooling with ice;

DOI:10.1016/j.bmcl.2010.12.126

upstream raw materials:

1H-imidazole

imidazole-1-sulfonyl azide hydrochloride

Refernces

• 1、 Peng, Chi-Jiun,Chen, Hsiu-Ling,Chiu, Cheng-Hsun,Fang, Jim-Min. "Site-Selective Functionalization of Flagellin by Steric Self-Protection: A Strategy To Facilitate Flagellin as a Self-Adjuvanting Carrier in Conjugate Vaccine". . p. 805 - 814. Retrieved 2018.
• 2、 Meyer, Christoph,Hoeger, Birgit,Chatterjee, Jayanta,K?hn, Maja. "Azide-alkyne cycloaddition-mediated cyclization of phosphonopeptides and their evaluation as PTP1B binders and enrichment tools". . p. 2848 - 2853. Retrieved 2015.
• 3、 Tosh, Dilip K.,Yoo, Lena S.,Chinn, Moshe,Hong, Kunlun,Kilbey II, S. Michael,Barrett, Matthew O.,Fricks, Ingrid P.,Harden, T. Kendall,Gao, Zhan-Guo,Jacobson, Kenneth A.. "Polyamidoamine (PAMAM) dendrimer conjugates of clickable agonists of the A3 adenosine receptor and coactivation of the P2Y14 receptor by a tethered nucleotide". . p. 372 - 384. Retrieved 2010.
• 4、 Darses, Benjamin,Maldivi, Pascale,Philouze, Christian,Dauban, Philippe,Poisson, Jean-Fran?ois. "Asymmetric Intramolecular Buchner Reaction: From High Stereoselectivity to Coexistence of Norcaradiene, Cycloheptatriene, and an Intermediate Form in the Solid State". supporting information. p. 300 - 304. Retrieved 2021/01/26.
• 5、 Bols, Mikael,Diness, Frederik,J?rgensen, Frederik P.,Madsen, Daniel,Meldal, Morten,Olsen, Jakob V.,Palmer, Daniel,Roux, Milena E.,Schoffelen, Sanne. "Design and Combinatorial Development of Shield-1 Peptide Mimetics Binding to Destabilized FKBP12". supporting information. . Retrieved 2020/03/10.