3-CHLORO-4-(TRIFLUOROMETHYL)BENZONITRILE

Base Information

• Chemical Name: 3-CHLORO-4-(TRIFLUOROMETHYL)BENZONITRILE
• CAS No.: 1092460-79-1
• Molecular Formula: C8H3ClF3N
• Molecular Weight: 205.567
• Hs Code.: 2926909090
• Mol file: 1092460-79-1.mol

Synonyms:3-CHLORO-4-(TRIFLUOROMETHYL)BENZONITRILE

Chemical Property of 3-CHLORO-4-(TRIFLUOROMETHYL)BENZONITRILE

Chemical Property:

• Boiling Point: 226.5±40.0 °C(Predicted)
• PSA: 23.79000
• Density: 1.43±0.1 g/cm3(Predicted)
• LogP: 3.23048
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3-Chloro-4-(trifluoromethyl)benzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CHLORO-4-(TRIFLUOROMETHYL)BENZONITRILE

There total 1 articles about 3-CHLORO-4-(TRIFLUOROMETHYL)BENZONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

zinc(II) cyanide (557-21-1) + 2,4-dichloro-benzotrifluoride (320-60-5) → 3-chloro-4-(trifluoromethyl)benzonitrile (1092460-79-1)

Guidance literature:

zinc(II) cyanide; With aluminum oxide; Ni(xantphos)(o-tolyl)Cl; for 1h; Schlenk technique; Inert atmosphere; Sealed tube;

2,4-dichloro-benzotrifluoride; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c7ob00892a

Reference yield: 74.0%

3-chloro-4-(trifluoromethyl)benzonitrile (1092460-79-1) → 3-chloro-4-(trifluoromethyl)benzaldehyde (83279-38-3)

Guidance literature:

3-chloro-4-(trifluoromethyl)benzonitrile; With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 4h;

With hydrogenchloride; water; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 1.5h;

Reference yield:

3-chloro-4-(trifluoromethyl)benzonitrile (1092460-79-1) → 3-chloro-4-(trifluoromethyl)benzamidine hydrochloride

Guidance literature:

3-chloro-4-(trifluoromethyl)benzonitrile; With hydrogenchloride; In methanol; chloroform; at 0 ℃; for 0.75h;

With ammonia; In methanol; at 20 ℃; Inert atmosphere;

upstream raw materials:

zinc(II) cyanide

2,4-dichloro-benzotrifluoride

Downstream raw materials:

3-chloro-4-(trifluoromethyl)benzaldehyde

Refernces