N-(5-bromopyridin-3-yl)-N-(methylsulfonyl)methanesulfonamide

Base Information

• Chemical Name: N-(5-bromopyridin-3-yl)-N-(methylsulfonyl)methanesulfonamide
• CAS No.: 1217273-00-1
• Molecular Formula: C7H9BrN2O4S2
• Molecular Weight: 329.195
• Hs Code.: 2935009090
• Mol file: 1217273-00-1.mol

Synonyms:N-(5-bromopyridin-3-yl)-N-(methylsulfonyl)methanesulfonamide

Chemical Property of N-(5-bromopyridin-3-yl)-N-(methylsulfonyl)methanesulfonamide

Chemical Property:

• PSA: 101.17000
• LogP: 2.73130
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

N-(5-Bromopyridin-3-yl)-N-(methylsulfonyl)methanesulfonamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(5-bromopyridin-3-yl)-N-(methylsulfonyl)methanesulfonamide

There total 1 articles about N-(5-bromopyridin-3-yl)-N-(methylsulfonyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3-amino-5-bromopyridine (13535-01-8) + methanesulfonyl chloride (124-63-0) → N-(5-bromopyridin-3-yl)-N-(methylsulfonyl)methanesulfonamide (1217273-00-1)

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 8h; Inert atmosphere;

DOI:10.1021/ol100011n

Reference yield: 48.0%

N-(5-bromopyridin-3-yl)-N-(methylsulfonyl)methanesulfonamide (1217273-00-1) + 7-(4-methoxyphenyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione (1217272-70-2) → N-(5-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)pyridin-3-yl)methanesulfonamide (1217272-84-8)

Guidance literature:

N-(5-bromopyridin-3-yl)-N-(methylsulfonyl)methanesulfonamide; 7-(4-methoxyphenyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione; With copper(l) iodide; palladium diacetate; caesium carbonate; In N,N-dimethyl-formamide; at 130 - 140 ℃; for 40h; Inert atmosphere; Sealed tube;

With water; In dichloromethane; N,N-dimethyl-formamide; Inert atmosphere;

DOI:10.1021/ol100011n

upstream raw materials:

3-amino-5-bromopyridine

methanesulfonyl chloride

Downstream raw materials:

N-(5-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)pyridin-3-yl)methanesulfonamide

Refernces