Icotinib (Hydrochloride)

Base Information

• Chemical Name: Icotinib (Hydrochloride)
• CAS No.: 1204313-51-8
• Molecular Formula: C₂₂H₂₁N₃O₄*ClH
• Molecular Weight: 427.887
• Mol file: 1204313-51-8.mol

Synonyms:Icotinib (Hydrochloride)

Chemical Property of Icotinib (Hydrochloride)

Chemical Property:

• PSA: 74.73000
• LogP: 4.03410
• Solubility.: Soluble in DMSO

Purity/Quality:

98%, ^*data from raw suppliers

IcotinibHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Clinical Use: Icotinib hydrochloride, developed by the Chinese pharmaceutical company Zhejiang Bata Pharma Inc., is a potent small molecule epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor for the treatment of non-small cell lung cancer (NSCLC). It was first approved by the SFDA of China, and launched under the brand name Conmana in the middle of 2011, representing an important milestone for Chinese pharmaceutical research and development. As the third EGFR-TKI drug targeting NSCLS therapy, icotinib hydrochloride possesses a similar structure to gefitinib (Iressa, AstraZeneca) and erlotinib (Tarceva, OST & Roche). Interestingly, a randomized, double-blind phase III clinical study of icotinib versus gefitinib in 399 patients with advanced NSCLC demonstrated that icotinib provides similar efficacy to gefitinib, but with better tolerability in NSCLC patients previously treated with one or two chemotherapy agents.