Methyl 3-iodopyrazine-2-carboxylate

Base Information

• Chemical Name: Methyl 3-iodopyrazine-2-carboxylate
• CAS No.: 173290-17-0
• Molecular Formula: C₆H₅IN₂O₂
• Molecular Weight: 264.022
• Hs Code.: 2933998090
• Mol file: 173290-17-0.mol

Synonyms:2-pyrazinecarboxylic acid, 3-iodo-, methyl ester;Methyl 3-iodopyrazine-2-carboxylate;LogP

Chemical Property of Methyl 3-iodopyrazine-2-carboxylate

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Boiling Point: 292.648°C at 760 mmHg
• Flash Point: 130.789°C
• PSA: 52.08000
• Density: 1.944g/cm³
• LogP: 0.86780
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

Methyl3-iodopyrazine-2-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 3-iodopyrazine-2-carboxylate

There total 1 articles about Methyl 3-iodopyrazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

Methyl 3-amino-2-pyrazinecarboxylate (16298-03-6) → methyl 3-iodopyrazine-2-carboxylate (173290-17-0)

Guidance literature:

With diiodomethane; isopentyl nitrite; In diiodomethane; at 85 - 100 ℃; for 15h;

Reference yield: 24.0%

C16H15F7N2O + methyl 3-iodopyrazine-2-carboxylate (173290-17-0) → methyl 3-((1R,5S)-3-(2-methyl-1-oxo-1-((2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)amino)propan-2-yl)-3-azabicyclo[3.1.0]hexan-6-yl)pyrazine-2-carboxylate

Guidance literature:

With 6-methyl-2-pyridinecarboxylic acid; palladium diacetate; cesium pivalate; In tert-Amyl alcohol; at 130 ℃; Sealed tube;

DOI:10.1021/acs.joc.0c00870

Reference yield:

2-bromoanisole (578-57-4) + methyl 3-iodopyrazine-2-carboxylate (173290-17-0) → 3-(2-Methoxy-phenyl)-pyrazine-2-carboxylic acid methyl ester

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; Trimethyl borate; hydrogen cation; potassium carbonate; Multistep reaction;

DOI:10.1111/j.1751-1097.1997.tb08637.x

upstream raw materials:

Methyl 3-amino-2-pyrazinecarboxylate

Refernces

• 1、 -. "NOVEL COMPOUND HAVING 4-PYRIDYLALKYLTHIO GROUP AS SUBSTITUENT". Page/Page column 58. . Retrieved 2008/06/13.