4-METHYL-5-CYANO-(1H)INDAZOLE

Base Information

• Chemical Name: 4-METHYL-5-CYANO-(1H)INDAZOLE
• CAS No.: 478837-29-5
• Molecular Weight: 157.17
• Mol file: 478837-29-5.mol

Synonyms:

Chemical Property of 4-METHYL-5-CYANO-(1H)INDAZOLE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Storage Temp.: 2-8°C

Purity/Quality:

95% ^*data from raw suppliers

4-Methyl-5-cyano-(1H)indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHYL-5-CYANO-(1H)INDAZOLE

There total 6 articles about 4-METHYL-5-CYANO-(1H)INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.9%

N-(4-cyano-2,3-dimethylphenyl)acetamide (478837-27-3) → 4-methyl-1H-indazole-5-carbonitrile (478837-29-5)

Guidance literature:

With potassium acetate; acetic anhydride; N-butylammonium bromide; isopentyl nitrite; In ethyl acetate; for 7h; Heating / reflux;

Reference yield: 38.0%

sodium cyanide (773837-37-9) + copper(l) cyanide + 4-methyl-1(2)H-indazol-5-ylamine (101257-89-0) → 4-methyl-1H-indazole-5-carbonitrile (478837-29-5)

Guidance literature:

4-methyl-1⁽²⁾H-indazol-5-ylamine; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h;

sodium cyanide; copper(l) cyanide; In water; ethyl acetate; at 0 - 50 ℃; for 3.5h;

Reference yield:

4-amino-2,3-dimethylbenzonitrile (478837-24-0) → 4-methyl-1H-indazole-5-carbonitrile (478837-29-5)

Guidance literature:

Multi-step reaction with 2 steps

1: ethyl acetate / 4 h / Heating / reflux

2: potassium acetate; acetic anhydride; N-butylammonium bromide; isopentyl nitrite / ethyl acetate / 7 h / Heating / reflux

With potassium acetate; acetic anhydride; N-butylammonium bromide; isopentyl nitrite; In ethyl acetate;

upstream raw materials:

N-(4-cyano-2,3-dimethylphenyl)acetamide

sodium cyanide

4-methyl-1(2)H-indazol-5-ylamine

4-amino-2,3-dimethylbenzonitrile

Refernces

• 1、 -. "Rho KINASE INHIBITORS". Page 128. . Retrieved 2010/02/06.