(S)-Piperidine-2-carboxamide hydrochloride

Base Information

• Chemical Name: (S)-Piperidine-2-carboxamide hydrochloride
• CAS No.: 78058-42-1
• Molecular Formula: C6H12N2O.ClH
• Molecular Weight: 164.63322
• Mol file: 78058-42-1.mol

Synonyms:(S)-piperidine-2-carboxylic acid amide hydrochloride;(R)-2',6'-pipecoloxylidide;(2S)-N-(2,6-diMethylphenyl)piperidine-2-carboxaMide;(2S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide);N-Desbutyl (S)-Bupivacaine;(2S)-(2,6-dimethyl phenyl) piperidine-2-carboxamide;(S)-N-(2',6'-DIMETHYLPHENYL)-2-PIPERIDINE CARBOXAMIDE;(2S)-piperidine-2-carboxamide hydrochloride;L-Pipecolic acid 2,6-xylidide;(S)-(+)-Pipecolinoxylidide;(S)-N-(2',6'-dimethylphenl)-2-Piperidine carboxamide;(S)-piperidine-2-carboxylic acid 2,6-dimethylphenyl amide;(S)-2',6'-pipecoloxylidide;L-piperidine-2-carboxamide hydrochloride;L-Homoprolinamide hydrochloride;(+)-2',6'-pipecoloxylidide;N-Despropyl Ropivacaine;N-DesMethyl (S)-Mepivacaine;(S)-pipecoloxylidide;

Chemical Property of (S)-Piperidine-2-carboxamide hydrochloride

Chemical Property:

• PSA: 56.11000
• LogP: 1.89430

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-Piperidine-2-carboxamide hydrochloride

There total 3 articles about (S)-Piperidine-2-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-2-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester (78058-41-0) → L-piperidine-2-carboxamide hydrochloride (78058-42-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 0.75h; Ambient temperature;

DOI:10.1021/jm00160a051

Reference yield: 100.0%

→ L-piperidine-2-carboxamide hydrochloride (78058-42-1)

Guidance literature:

Reference yield:

(S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid (26250-84-0) → L-piperidine-2-carboxamide hydrochloride (78058-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Et₃N, ethyl chloroformate, 2.) conc. NH₄OH / 1.) THF, -10 deg C, 2.) THF, RT, 4 h

2: 100 percent / 4 N aq. HCl / dioxane / 0.75 h / Ambient temperature

With hydrogenchloride; ammonium hydroxide; chloroformic acid ethyl ester; triethylamine; In 1,4-dioxane;

DOI:10.1021/jm00160a051

upstream raw materials:

(S)-2-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester

(S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid

Refernces

• 1、 -. "PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSHORYLASE". Page 60. . Retrieved 2008/06/13.
• 2、 -. "Tripeptides acting on the central nervous system and a process for the preparation thereof". . . Retrieved 2008/06/13.