N3PT

Base Information

• Chemical Name: N3PT
• CAS No.: 13860-66-7
• Molecular Formula: C13H19Cl2N3OS
• Molecular Weight: 336.28046
• Mol file: 13860-66-7.mol

Synonyms:N3PT;N3-pyridyl thiaMine;3-[(2-Amino-6-methyl-3-pyridyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium chloride hydrochloride

Chemical Property of N3PT

Chemical Property:

• Melting Point: 225℃
• PSA: 91.26000
• LogP: -0.40010
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

>98% ^*data from raw suppliers

N3PT >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N3PT

There total 5 articles about N3PT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

5-hydroxyethyl-4-methylthiazole (137-00-8,8042-97-5) + 3-(chloromethyl)-6-methylpyridin-2-ylamine hydrochloride → 3-(2-amino-6-methyl-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium chloride hydrochloride (13860-66-7)

Guidance literature:

at 100 ℃;

DOI:10.1016/j.bmcl.2007.11.101

Reference yield:

1-(3-chloro-2-hydroxy-2-methyl-tetrahydro-[3]furyl)-ethanone → 3-(2-amino-6-methyl-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium chloride hydrochloride (13860-66-7)

Guidance literature:

With sodium hydrogensulfide; weiteres Edukt: N-<2-Amino-6-methyl-<3>pyridylmethyl>-formamid; Reaktion ueber mehrere Stufen;

Reference yield:

5-Acetoxy-3-chloropentan-2-one (13051-49-5) → 3-(2-amino-6-methyl-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium chloride hydrochloride (13860-66-7)

Guidance literature:

With sodium hydrogensulfide; weiteres Edukt: N-<2-Amino-6-methyl-<3>pyridylmethyl>-formamid; Reaktion ueber mehrere Stufen;

upstream raw materials:

5-hydroxyethyl-4-methylthiazole

5-Acetoxy-3-chloropentan-2-one

6-methyl-2-amino-3-hydroxymethylpyridine

ethyl 2-amino-6-methylnicotinate

Downstream raw materials:

2-(2,7-dimethyl-10-phenyl-5,10-dihydro-pyrido[2',3':4,5]pyrimido[2,1-c][1,4]thiazin-8-yl)-ethanol

Refernces

• 1、 -. "THIOALKENEAMIDES AS TRANSKETOLASE INHIBITORS". Page/Page column 37. . Retrieved 2008/06/13.