Temsirolimus Acetonide

Base Information

• Chemical Name: Temsirolimus Acetonide
• CAS No.: 162635-03-2
• Molecular Formula: C59H91NO16
• Molecular Weight: 1070.37
• Mol file: 162635-03-2.mol

Synonyms:Rapamycin 42-(2,2,5-Trimethyl-1,3-dioxane-5-carboxylate);

Chemical Property of Temsirolimus Acetonide

Chemical Property:

• Melting Point: 89-91°C
• PSA: 219.96000
• LogP: 7.45860
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: Chloroform, Methanol

Purity/Quality:

97% ^*data from raw suppliers

TemsirolimusAcetonide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Rapamycin 42-ester derivative Rapamycin 42-ester derivative.

Technology Process of Temsirolimus Acetonide

There total 9 articles about Temsirolimus Acetonide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2,2,5-trimethyl-1,3-dioxane-5-carboxylic acid chloride (331810-11-8) + sirolimus (53123-88-9) → rapamycin 42-ester with 2,2,5-trimethyl[1,3]dioxane-5-carboxylic acid (162635-03-2)

Guidance literature:

With pyridine; In dichloromethane; at 5 ℃; for 24h; Product distribution / selectivity;

Reference yield: 42.1%

2,4,6-trichlorobenzoic-2',2',5'-trimethyl-1',3'-dioxane-5'-carboxylic anhydride (162635-10-1) + C52H81NO15S → rapamycin 42-ester with 2,2,5-trimethyl[1,3]dioxane-5-carboxylic acid (162635-03-2)

Guidance literature:

With dmap; In dichloromethane; at -20 ℃; Inert atmosphere;

Reference yield: 34.0%

2,2,5-trimethyl-1,3-dioxane-5-carboxylic acid (16837-14-2) + sirolimus (53123-88-9) → rapamycin 42-ester with 2,2,5-trimethyl[1,3]dioxane-5-carboxylic acid (162635-03-2)

Guidance literature:

2,2,5-trimethyl-1,3-dioxane-5-carboxylic acid; With 2,4,6-trichlorobenzoyl chloride; triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 5h;

sirolimus; With dmap; In benzene; at 20 ℃;

upstream raw materials:

2,2,5-trimethyl-[1,3]dioxane-5-carboxylic acid vinyl ester

sirolimus

2,2,5-trimethyl-1,3-dioxane-5-carboxylic acid

2,2,5-trimethyl-1,3-dioxane-5-carboxylic acid chloride

Downstream raw materials:

temsirolimus

Refernces

• 1、 -. "Method for preparing temsirolimus". . . Retrieved 2018/04/03.
• 2、 -. "Preparation method for temsirolimus". . . Retrieved 2019/01/08.