Technology Process of S-(4-Nitrobenzyl)-6-thioinosine
There total 7 articles about S-(4-Nitrobenzyl)-6-thioinosine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
6-Chloropurine riboside;
With
pyridine; trityl resin;
for 48h;
(p-nitrophenyl)methanethiol;
With
triethylamine;
In
methanol;
at 55 ℃;
for 5h;
With
chlorotriisopropylsilane; trifluoroacetic acid;
In
dichloromethane;
for 0.166667h;
DOI:10.1021/jm030537y
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 94 percent / hexamethyldisilazane; Me3SiCl; trimethylsilyl triflate / acetonitrile / 2.5 h / Heating
2.1: 36 percent / NH3 / methanol / 20 °C
3.1: trityl resin; pyridine / 48 h
3.2: Et3N / methanol / 5 h / 55 °C
3.3: 94 percent / triisopropylsilane; trifluoroacetic acid / CH2Cl2 / 0.17 h
With
pyridine; chloro-trimethyl-silane; trityl resin; trimethylsilyl trifluoromethanesulfonate; ammonia; 1,1,1,3,3,3-hexamethyl-disilazane;
In
methanol; acetonitrile;
DOI:10.1021/jm030537y
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 94 percent / hexamethyldisilazane; Me3SiCl; trimethylsilyl triflate / acetonitrile / 2.5 h / Heating
2.1: 36 percent / NH3 / methanol / 20 °C
3.1: trityl resin; pyridine / 48 h
3.2: Et3N / methanol / 5 h / 55 °C
3.3: 94 percent / triisopropylsilane; trifluoroacetic acid / CH2Cl2 / 0.17 h
With
pyridine; chloro-trimethyl-silane; trityl resin; trimethylsilyl trifluoromethanesulfonate; ammonia; 1,1,1,3,3,3-hexamethyl-disilazane;
In
methanol; acetonitrile;
DOI:10.1021/jm030537y
