Technology Process of 2-hydrazinyl-5-[(4-methylphenyl)sulfonyl]-5H-Pyrrolo[2,3-b]pyrazine
There total 4 articles about 2-hydrazinyl-5-[(4-methylphenyl)sulfonyl]-5H-Pyrrolo[2,3-b]pyrazine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C23H29N5O6S;
With
phosphoric acid;
In
tetrahydrofuran; n-heptane;
at 70 ℃;
for 2h;
With
potassium carbonate;
In
water;
at 20 ℃;
for 1h;
DOI:10.1016/j.bmcl.2012.11.108
- Guidance literature:
-
t-butoxycarbonylhydrazine; 2-bromo-5-(4-methylbenzenesulfonyl)-5H-pyrrolo[2,3-b]pyrazine;
With
sodium t-butanolate; tert-butyl XPhos;
tris-(dibenzylideneacetone)dipalladium(0);
In
1,4-dioxane;
at 80 ℃;
for 0.833333h;
With
hydrogenchloride;
In
1,4-dioxane;
at 60 ℃;
for 1h;
With
sodium hydrogencarbonate;
In
water;
for 1h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C
2.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium carbonate / 1,4-dioxane; tert-Amyl alcohol / 2 h / 95 °C
3.1: phosphoric acid / tetrahydrofuran; n-heptane / 2 h / 70 °C
3.2: 1 h / 20 °C
With
phosphoric acid; palladium diacetate; sodium hydride; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
tetrahydrofuran; 1,4-dioxane; tert-Amyl alcohol; n-heptane; N,N-dimethyl-formamide;
2.1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmcl.2012.11.108