HP 236

Base Information

• Chemical Name: HP 236
• CAS No.: 131540-59-5
• Molecular Formula: C₂₂H₃₀FN₃OS₂
• Molecular Weight: 435.63
• Mol file: 131540-59-5.mol

Synonyms:HP 236

Chemical Property of HP 236

Chemical Property:

• Vapor Pressure: 1.25E-14mmHg at 25°C
• Boiling Point: 605.9°Cat760mmHg
• Flash Point: 320.2°C
• PSA: 80.33000
• Density: 1.205g/cm³
• LogP: 4.58340

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of HP 236

There total 5 articles about HP 236 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(4-bromobutyl)-2,5,5-trimethyl-4-thiazolidinone (131540-78-8) + 1-(6-fluorobenzo[b]thiophen-3-yl)-piperazine (131540-84-6) → 3-<4-<1-(6-fluorobenzothiophen-3-yl)-4-piperazinyl>butyl>-2,5,5-trimethyl-4-thiazolidinone (131540-59-5)

Guidance literature:

With potassium carbonate; sodium iodide; In acetonitrile; Heating;

DOI:10.1021/jm00092a024

Reference yield:

2,4-difluorobenzonitrile (3939-09-1,103496-86-2) → 3-<4-<1-(6-fluorobenzothiophen-3-yl)-4-piperazinyl>butyl>-2,5,5-trimethyl-4-thiazolidinone (131540-59-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 8.65 g / LiOH*H₂O / dimethylformamide / -10 °C

2: 1-methylpiperazine / various solvent(s) / 2 h / 176 °C

3: various solvent(s) / 14 h / 186 - 192 °C

4: 3.40 g / K₂CO₃, NaI / acetonitrile / 16 h / 50 °C

With 1-methyl-piperazine; lithium hydroxide; potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm960268u

Reference yield:

3-amino-6-fluorobenzothiophene (142364-00-9) → 3-<4-<1-(6-fluorobenzothiophen-3-yl)-4-piperazinyl>butyl>-2,5,5-trimethyl-4-thiazolidinone (131540-59-5)

Guidance literature:

Multi-step reaction with 2 steps

1: various solvent(s) / 14 h / 186 - 192 °C

2: 3.40 g / K₂CO₃, NaI / acetonitrile / 16 h / 50 °C

With potassium carbonate; sodium iodide; In acetonitrile;

DOI:10.1021/jm960268u

upstream raw materials:

3-(4-bromobutyl)-2,5,5-trimethyl-4-thiazolidinone

1-(6-fluorobenzo[b]thiophen-3-yl)-piperazine

2,4-difluorobenzonitrile

3-amino-6-fluorobenzothiophene

Refernces

• 1、 Hrib, Nicholas J.,Jurcak, John G.,Bregna, Deborah E.,Burgher, Kendra L.,Hartman, Harold B.,Kafka, Sharon,Kerman, Lisa L.,Kongsamut, Sam,Roehr, Joachim E.,Szewczak, Mark R.,Woods-Kettelberger, Ann T.,Corbett, Roy. "Structure-activity relationships of a series of novel (piperazinylbutyl)thiazolidinone antipsychotic agents related to 3-[4-[4-(6- fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]-2,5,5-trimethyl-4- thiazolidinone maleate". . p. 4044 - 4057. Retrieved 2007/10/03.
• 2、 -. "3-[4-(1-Substituted-4-piperazinyl)butyl]-4-thiazolidinone compounds". . . Retrieved 2008/06/13.