2-(4-FLUOROPHENYL)SUCCINIC ACID

Base Information

• Chemical Name: 2-(4-FLUOROPHENYL)SUCCINIC ACID
• CAS No.: 833-18-1
• Molecular Formula: C10H9FO4
• Molecular Weight: 212.17
• Mol file: 833-18-1.mol

Synonyms:2-(4-FLUOROPHENYL)SUCCINIC ACID;CBI-BB ZERO/006514

Chemical Property of 2-(4-FLUOROPHENYL)SUCCINIC ACID

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-(4-fluorophenyl)succinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-FLUOROPHENYL)SUCCINIC ACID

There total 5 articles about 2-(4-FLUOROPHENYL)SUCCINIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

C18H24FN3O4 (109971-37-1) → 3-(4-Fluorophenyl)succinic acid (833-18-1)

Guidance literature:

With hydrogenchloride; for 10h; Heating;

DOI:10.1055/s-1986-31770

Reference yield: 81.0%

para-fluorostyrene (405-99-2) + carbon dioxide (124-38-9,18923-20-1) → 3-(4-fluorophenyl)propanoic acid (459-31-4) + 3-(4-Fluorophenyl)succinic acid (833-18-1)

Guidance literature:

With 1,2,2,6,6-pentamethylpiperidine; [1,1';4',1'']terphenyl; water; In hexane; N,N-dimethyl-formamide; at 35 - 38 ℃; for 0.133333h; under 760.051 Torr; Schlenk technique; UV-irradiation; Flow reactor;

DOI:10.1021/jacs.7b05942

Reference yield: 81.0%

→ 3-(4-Fluorophenyl)succinic acid (833-18-1)

Guidance literature:

With (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; caesium carbonate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25 ℃; for 48h; under 760.051 Torr; Schlenk technique; Glovebox; Irradiation;

With hydrogenchloride; In water; N,N-dimethyl-formamide;

upstream raw materials:

C₁₈H₂₄FN₃O₄

4-fluoro-β-nitrostyrene

para-fluorostyrene

carbon dioxide

Refernces

• 1、 Seo, Hyowon,Liu, Aofei,Jamison, Timothy F.. "Direct β-Selective Hydrocarboxylation of Styrenes with CO2 Enabled by Continuous Flow Photoredox Catalysis". supporting information. p. 13969 - 13972. Retrieved 2017/10/17.