N-(4-Methylthiazol-2-yl)acetamide

Base Information Edit

Chemical Name:N-(4-Methylthiazol-2-yl)acetamide
CAS No.:7336-51-8
Molecular Formula:C6H8N2OS
Molecular Weight:156.208
Hs Code.:2934100090
European Community (EC) Number:628-103-1
NSC Number:133181
DSSTox Substance ID:DTXSID70299843
Nikkaji Number:J265.570E
Wikidata:Q27456548
ChEMBL ID:CHEMBL71189
Mol file:7336-51-8.mol

Synonyms:7336-51-8;N-(4-Methylthiazol-2-yl)acetamide;2-Acetamido-4-methylthiazole;N-(4-Methyl-1,3-thiazol-2-yl)acetamide;MFCD00011561;acetamide, n-(4-methyl-2-thiazolyl)-;NA inhibitor, 1;NSC133181;TimTec1_001740;SCHEMBL48394;MLS001005634;2-Acetamido-4-methyl-thiazol;CHEMBL71189;DTXSID70299843;CHEBI:195019;BDBM234413;HMS1538P02;HMS2720N19;AMY14509;2-Acetamido-4-methyl-1,3-thiazole;2-Acetamido-4-methylthiazole, 98%;CCG-49407;STK325970;AKOS001033525;N-(4-Methyl-thiazol-2-yl)-acetamide;CS-W016233;NSC-133181;NCGC00174114-01;CS-15496;SMR000348925;SY045700;N1-(4-methyl-1,3-thiazol-2-yl)acetamide;FT-0636440;N-(4-Methyl-1,3-thiazol-2-yl)acetamide #;A837810;AB-601/30915053;SR-01000396372;NSC 133181;SR-01000396372-1;SR-01000396372-2;Q27456548;Z30820114;F0273-0043;InChI=1/C6H8N2OS/c1-4-3-10-6(7-4)8-5(2)9/h3H,1-2H3,(H,7,8,9;6T4

Suppliers and Price of N-(4-Methylthiazol-2-yl)acetamide

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
2-Acetamido-4-methylthiazole
2.5g
$ 418.00

Sigma-Aldrich
2-Acetamido-4-methylthiazole 98%
5g
$ 99.20

Sigma-Aldrich
2-Acetamido-4-methylthiazole 98%
25g
$ 386.00

Matrix Scientific
N-(4-Methylthiazol-2-yl)acetamide 97%
10g
$ 685.00

Crysdot
N-(4-Methylthiazol-2-yl)acetamide 95+%
1g
$ 381.00

Chemenu
N-(4-methylthiazol-2-yl)acetamide 95%
1g
$ 356.00

Biosynth Carbosynth
2-Acetamido-4-methylthiazole
50 g
$ 450.00

Biosynth Carbosynth
2-Acetamido-4-methylthiazole
2 g
$ 50.00

Biosynth Carbosynth
2-Acetamido-4-methylthiazole
25 g
$ 275.00

Biosynth Carbosynth
2-Acetamido-4-methylthiazole
10 g
$ 150.00

Total 30 raw suppliers

Chemical Property of N-(4-Methylthiazol-2-yl)acetamide Edit

Chemical Property:

Melting Point:134-136 °C(lit.)
Refractive Index:1.604
PKA:9.70±0.50(Predicted)
PSA：70.23000
Density:1.285 g/cm³
LogP:1.48290
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:156.03573406
Heavy Atom Count:10
Complexity:140

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Acetamido-4-methylthiazole ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC1=CSC(=N1)NC(=O)C
Uses 2-Acetamido-4-methylthiazole, is a benzothiazinone analog, which is shown to be the xanthine oxidase inhibitor.

Technology Process of N-(4-Methylthiazol-2-yl)acetamide

There total 13 articles about N-(4-Methylthiazol-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1603-91-4
4-methylthiazol-2-ylamine

: 108-24-7
acetic anhydride

: 7336-51-8
2-acetamido-4-methylthiazole

Guidance literature:: at 20 - 80 ℃; for 3h;
DOI:10.1016/j.bmcl.2015.11.097

Reference yield: 82.0%

: 1603-91-4
4-methylthiazol-2-ylamine

: 64-19-7,77671-22-8
acetic acid

: 7336-51-8
2-acetamido-4-methylthiazole

Guidance literature:: With HATU; potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 8h;
DOI:10.1016/j.ejmech.2020.112744

Reference yield: 12.0%

: 1461-22-9
tributyltin chloride

: 7336-51-8
2-acetamido-4-methylthiazole

: 944994-27-8
N-[4-methyl-5-(tributylstannyl)-1,3-thiazol-2-yl]acetamide

Guidance literature:: N-(5-iodo-4-methyl-thiazol-2-yl)acetamide; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 2h;

tributyltin chloride; In tetrahydrofuran; at -78 - 20 ℃; for 6h;

With water; ammonium chloride; In tetrahydrofuran;