2-(Aminoethyl)-1-N-boc-piperidine

Base Information

• Chemical Name: 2-(Aminoethyl)-1-N-boc-piperidine
• CAS No.: 239482-98-5
• Molecular Formula: C12H24N2O2
• Molecular Weight: 228.335
• Hs Code.: 29333990
• European Community (EC) Number: 672-201-7
• DSSTox Substance ID: DTXSID10373358
• Mol file: 239482-98-5.mol

Synonyms:2-(AMINOETHYL)-1-N-BOC-PIPERIDINE;239482-98-5;Tert-butyl 2-(2-aminoethyl)piperidine-1-carboxylate;1-boc-2-(aminoethyl)piperidine;2-aminoethyl-1-n-boc-piperidine;2-(aminoethyl)-1-boc-piperidine;2-(2-amino-ethyl)-piperidine-1-carboxylic acid tert-butyl ester;2-(2-Aminoethyl)-1-Boc-piperidine;SCHEMBL1009587;2-Aminoethylpiperidine-1-carboxylic acid tert-butyl ester;DTXSID10373358;QLEBCEWTHGUFFL-UHFFFAOYSA-N;2-(aminoethyl)-1-n-bocpiperidine;MFCD01631187;AKOS013064870;AB09338;AC-6577;AM81345;A4978;CS-0002016;FT-0630137;EN300-761079;2-(aminoethyl)-1-N-Boc-piperidine, AldrichCPR;J-506194;tert-Butyl 2-(2-aminoethyl)-1-piperidinecarboxylate;1-piperidinecarboxylic acid, 2-(2-aminoethyl)-, 1,1-dimethylethyl ester;tert-butyl 2-(2-aminoethyl)piperidine-1-carboxylate;2-(AMINOETHYL)-1-BOC-PIPERIDINE

Chemical Property of 2-(Aminoethyl)-1-N-boc-piperidine

Chemical Property:

• Vapor Pressure: 0.000422mmHg at 25°C
• Boiling Point: 316 °C at 760 mmHg
• PKA: 10.56±0.10(Predicted)
• Flash Point: 144.9 °C
• PSA: 55.56000
• Density: 1.01 g/cm³
• LogP: 2.76300
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 228.183778013
• Heavy Atom Count: 16
• Complexity: 236

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Aminoethyl)-1-N-Boc-piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn,N
• Statements: 36/37/38-50-22
• Safety Statements: 26-36/37/39-61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCCCC1CCN
• Uses: 2-(Aminoethyl)-1-N-Boc-piperidine is a useful research chemical.

Technology Process of 2-(Aminoethyl)-1-N-boc-piperidine

There total 2 articles about 2-(Aminoethyl)-1-N-boc-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H26N2O4 → 2-(2-Amino-ethyl)-piperidine-1-carboxylic acid t-butyl ester (239482-98-5)

Guidance literature:

With hydrazine; In ethanol; for 1h; Heating / reflux;

Reference yield:

2-(2-Azidoethyl)piperidine-1-carboxylic acid tert-butyl ester (741287-29-6) → 2-(2-Amino-ethyl)-piperidine-1-carboxylic acid t-butyl ester (239482-98-5)

Guidance literature:

palladium; In methanol;

Reference yield: 79.0%

2-(2-Amino-ethyl)-piperidine-1-carboxylic acid t-butyl ester (239482-98-5) + 3-bromo-7-chloro-5-(2-chlorophenyl)pyrazolo[1,5-a]pyrimidine (672323-76-1) → 2-{[3-bromo-5-(2-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-ylamino]ethyl}piperidine-1-carboxylic acid tert-butyl ester (672326-14-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 75 ℃; for 48h;

upstream raw materials:

2-(2-Azidoethyl)piperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

2-{[3-bromo-5-(2-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-ylamino]ethyl}piperidine-1-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "1H-imidazopyridine derivatives". . . Retrieved 2008/06/13.