1,3,5-trimethyl-2-(phenylsulfonyl)benzene

Base Information

• Chemical Name: 1,3,5-trimethyl-2-(phenylsulfonyl)benzene
• CAS No.: 3112-82-1
• Molecular Formula: C15H16 O2 S
• Molecular Weight: 260.357
• Mol file: 3112-82-1.mol

Synonyms:Sulfone,mesityl phenyl (6CI,7CI,8CI); 2,4,6-Trimethylphenyl phenyl sulfone; Mesitylphenyl sulfone; NSC 403306; Phenyl 2,4,6-trimethylphenyl sulfone

Chemical Property of 1,3,5-trimethyl-2-(phenylsulfonyl)benzene

Chemical Property:

• Vapor Pressure: 9.05E-07mmHg at 25°C
• Boiling Point: 416.7°Cat760mmHg
• Flash Point: 246.1°C
• Density: 1.148g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3,5-trimethyl-2-(phenylsulfonyl)benzene

There total 30 articles about 1,3,5-trimethyl-2-(phenylsulfonyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

benzenesulfonyl chloride (98-09-9) + 1,3,5-trimethyl-benzene (108-67-8) → (2,4,6-trimethylphenyl) phenyl sulfone (3112-82-1)

Guidance literature:

With tin(II) trifluoromethanesulfonate; at 120 ℃; for 8h;

DOI:10.1016/S0040-4020(00)01005-X

Reference yield: 98.0%

mesityl(phenyl)iodonium triflouromethanesulfonate (144930-50-7) + phenylboronic acid (98-80-6) → (2,4,6-trimethylphenyl) phenyl sulfone (3112-82-1)

Guidance literature:

With potassium disulphite; 1,3-bis(2,6-di-i-propylphenyl)ylidene gold chloride; sodium carbonate; In acetonitrile; at 100 ℃; for 24h; chemoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.8b03957

Reference yield: 91.0%

bis(2,4,6-trimethylphenyl)iodonium triflate + sodium benzenesulfonate (873-55-2) → (2,4,6-trimethylphenyl) phenyl sulfone (3112-82-1)

Guidance literature:

In N,N-dimethyl-formamide; at 90 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1021/ol303248h

upstream raw materials:

phenyl mesityl sulfide

benzenesulfonyl chloride

1,3,5-trimethyl-benzene

2-mesitylenesulphonyl chloride

Downstream raw materials:

Benzenesulfinic acid

1,3,5-trimethyl-benzene

2-benzyl-4,6-dimethyl-benzenesulfinic acid

Refernces

• 1、 Feng, Yueji,Tuo, Yanyan,Zhang, Xiaohui,Zheng, Qing-Zhong. "Metal-free sulfonylation of arenes with: N -fluorobenzenesulfonimide via cleavage of S-N bonds: expeditious synthesis of diarylsulfones". supporting information. p. 768 - 772. Retrieved 2022/02/03.
• 2、 -. "Synthesis method of diaryl sulfone compound (by machine translation)". Paragraph 0007; 0017-0018; 0053-0055. . Retrieved 2019/12/31.